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2.A.39.3.8
Allantoin permease; encoded in an operon with allantoinase and other degradative enzymes (Moraes and Reithmeier 2012).

Accession Number:P75712
Protein Name:Putative allantoin permease
Length:484
Molecular Weight:52456.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Allantoin

Cross database links:

Genevestigator: P75712
EchoBASE: EB3383
EcoGene: EG13618
eggNOG: COG1953
HEGENOM: HOG000165632
Entrez Gene ID: 945138   
Pfam: PF02133   
KEGG: eco:b0511   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0006144 P:purine base metabolic process

References (4)

[1] “Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.”  Cusa E.et.al.   10601204
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEHQRKLFQQ RGYSEDLLPK TQSQRTWKTF NYFTLWMGSV HNVPNYVMVG GFFILGLSTF 
61:	SIMLAIILSA FFIAAVMVLN GAAGSKYGVP FAMILRASYG VRGALFPGLL RGGIAAIMWF 
121:	GLQCYAGSLA CLILIGKIWP GFLTLGGDFT LLGLSLPGLI TFLIFWLVNV GIGFGGGKVL 
181:	NKFTAILNPC IYIVFGGMAI WAISLVGIGP IFDYIPSGIQ KAENGGFLFL VVINAVVAVW 
241:	AAPAVSASDF TQNAHSFREQ ALGQTLGLVV AYILFAVAGV CIIAGASIHY GADTWNVLDI 
301:	VQRWDSLFAS FFAVLVILMT TISTNATGNI IPAGYQIAAI APTKLTYKNG VLIASIISLL 
361:	ICPWKLMENQ DSIYLFLDII GGMLGPVIGV MMAHYFVVMR GQINLDELYT APGDYKYYDN 
421:	GFNLTAFSVT LVAVILSLGG KFIHFMEPLS RVSWFVGVIV AFAAYALLKK RTTAEKTGEQ 
481:	KTIG