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2.A.4.1.1
Cd2+, Zn2+, Co2+ efflux permease (also binds Cu2+ and Ni2+) (Anton et al., 2004)

Accession Number:P13512
Protein Name:CzcD
Length:316
Molecular Weight:33707.00
Species:Alcaligenes eutrophus (Ralstonia eutropha) [266264]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cd2+, Zn2+, Co2+, Cu2+, Ni2+

Cross database links:

eggNOG: COG1230
HEGENOM: HBG317426
RefSeq: YP_145596.1    YP_581788.1   
Entrez Gene ID: 3170388    4036514   
Pfam: PF01545   
BioCyc: RMET266264:RMET_5979-MONOMER   
KEGG: rme:Rmet_5979   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0046686 P:response to cadmium ion
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (2)

[1] “Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus.”  Nies D.H.et.al.   2678100
[2] “Two-component regulatory system involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus.”  van der Lelie D.et.al.   9044283

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGAGHSHDHP GGNERSLKIA LALTGTFLIA EVVGGVMTKS LALISDAAHM LTDTVALAIA 
61:	LAAIAIAKRP ADKKRTFGYY RFEILAAAFN ALLLFGVAIY ILYEAYLRLK SPPQIESTGM 
121:	FVVAVLGLII NLISMRMLSS GQSSSLNVKG AYLEVWSDLL GSVGVIAGAI IIRFTGWAWV 
181:	DSAIAVLIGL WVLPRTWILL KSSLNVLLEG VPDDVDLAEV EKQILATPGV KSFHDLHIWA 
241:	LTSGKASLTV HVVNDTAVNP EMEVLPELKQ MLADKFDITH VTIQFELAPC EQADAAQHFN 
301:	ASPALVGSKS LAAGGN