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2.A.4.1.3
Cd2+ or Zn2+:H+ + K+ antiporter, CzcD

Accession Number:O07084
Protein Name:YRDO aka CZCD
Length:311
Molecular Weight:34163.00
Species:Bacillus subtilis [1423]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cd2+, Zn2+, H+, K+

Cross database links:

HEGENOM: HBG317426
RefSeq: NP_390542.1   
Entrez Gene ID: 937630   
Pfam: PF01545   
BioCyc: SUBTI:BSU26650-MONOMER   
KEGG: bsu:BSU26650   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0006824 P:cobalt ion transport
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (6)

[1] “Sequence of the Bacillus subtilis genome region in the vicinity of the lev operon reveals two new extracytoplasmic function RNA polymerase sigma factors SigV and SigZ.”  Sorokin A.et.al.   9308178
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “A Bacillus subtilis locus encoding several gene products affecting transport of cations.”  Sturr M.G.et.al.   9099864
[4] “Two types of Bacillus subtilis tetA(L) deletion strains reveal the physiological importance of TetA(L) in K(+) acquisition as well as in Na(+), alkali, and tetracycline resistance.”  Wang W.et.al.   10735849
[5] “An antiport mechanism for a member of the cation diffusion facilitator family: divalent cations efflux in exchange for K+ and H+.”  Guffanti A.A.et.al.   12100555
[6] “Genetic and physiological responses of Bacillus subtilis to metal ion stress.”  Moore C.M.et.al.   15948947

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGHNHNEGAN KKVLLISFIM ITGYMIIEAI GGFLTNSLAL LSDAGHMLSD SISLMVALIA 
61:	FTLAEKKANH NKTFGYKRFE ILAAVINGAA LILISLYIIY EAIERFSNPP KVATTGMLTI 
121:	SIIGLVVNLL VAWIMMSGGD TKNNLNIRGA YLHVISDMLG SVGAILAAIL IIFFGWGWAD 
181:	PLASIIVAIL VLRSGYNVTK DSIHILMEGT PENIDVSDII RTIEGTEGIQ NIHDLHIWSI 
241:	TSGLNALSCH AVVDDQLTIS ESENILRKIE HELEHKGITH VTIQMETEAH NHDNAILCQP 
301:	KMEKQRDHHH H