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2.A.4.1.4
Zn2+ (Km=105 μM), Cd2+ (Km=90 μM):proton (Km=20 nM) antiport metal ion efflux permease, ZitB (Chao and Fu, 2004a); Zn2+ (Km=1.4 μM; Anton et al., 2004). It also takes up Ni2+ and Cu2+ (Rahman et al., 2008).

Accession Number:P75757
Protein Name:ZitB
Length:313
Molecular Weight:34678.00
Species:Escherichia coli [83333]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Zn2+, Cd2+, H+

Cross database links:

Genevestigator: P75757
EchoBASE: EB3426
EcoGene: EG13662
eggNOG: COG1230
HEGENOM: HBG317426
RefSeq: AP_001383.1    NP_415273.1   
Entrez Gene ID: 945348   
Pfam: PF01545   
BioCyc: EcoCyc:B0752-MONOMER    ECOL168927:B0752-MONOMER   
KEGG: ecj:JW0735    eco:b0752   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (5)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “ZitB (YbgR), a member of the cation diffusion facilitator family, is an additional zinc transporter in Escherichia coli.”  Grass G.et.al.   11443104
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAHSHSHTSS HLPEDNNARR LLYAFGVTAG FMLVEVVGGF LSGSLALLAD AGHMLTDTAA 
61:	LLFALLAVQF SRRPPTIRHT FGWLRLTTLA AFVNAIALVV ITILIVWEAI ERFRTPRPVE 
121:	GGMMMAIAVA GLLANILSFW LLHHGSEEKN LNVRAAALHV LGDLLGSVGA IIAALIIIWT 
181:	GWTPADPILS ILVSLLVLRS AWRLLKDSVN ELLEGAPVSL DIAELKRRMC REIPEVRNVH 
241:	HVHVWMVGEK PVMTLHVQVI PPHDHDALLD QIQHYLMDHY QIEHATIQME YQPCHGPDCH 
301:	LNEGVSGHSH HHH