TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.4.3.6
solute carrier family 30 (zinc transporter), member 2

Accession Number:Q9BRI3
Protein Name:Zinc transporter 2
Length:323
Molecular Weight:35178.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Lysosome membrane1
Substrate Zn2+

Cross database links:

Genevestigator: Q9BRI3 Q9BRI3
eggNOG: COG1230 COG1230
HEGENOM: HOG000079023 HOG000079023
Entrez Gene ID: 7780   
Pfam: PF01545   
KEGG: hsa:7780    hsa:7780   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005770 C:late endosome
GO:0005765 C:lysosomal membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0061090 P:positive regulation of sequestering of zinc ion
GO:0006829 P:zinc ion transport
GO:0055085 P:transmembrane transport

References (8)

[1] “Large-scale cDNA transfection screening for genes related to cancer development and progression.”  Wan D.et.al.   15498874
[2] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319
[5] “Large-scale cDNA transfection screening for genes related to cancer development and progression.”  Wan D.et.al.   15498874
[6] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEAKEKQHLL DARPAIRSYT GSLWQEGAGW IPLPRPGLDL QAIELAAQSN HHCHAQKGPD 
61:	SHCDPKKGKA QRQLYVASAI CLLFMIGEVV EILGALVSVL SIWVVTGVLV YLAVERLISG 
121:	DYEIDGGTML ITSGCAVAVN IIMGLTLHQS GHGHSHGTTN QQEENPSVRA AFIHVIGDFM 
181:	QSMGVLVAAY ILYFKPEYKY VDPICTFVFS ILVLGTTLTI LRDVILVLME GTPKGVDFTA 
241:	VRDLLLSVEG VEALHSLHIW ALTVAQPVLS VHIAIAQNTD AQAVLKTASS RLQGKFHFHT 
301:	VTIQIEDYSE DMKDCQACQG PSD