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2.A.4.3.7
Zinc transporter 4 (ZnT-4) (Solute carrier family 30 member 4)

Accession Number:O14863
Protein Name:Zinc transporter 4
Length:429
Molecular Weight:47483.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: O14863
eggNOG: COG1230
HEGENOM: HOG000079023
Entrez Gene ID: 7782   
Pfam: PF01545   
KEGG: hsa:7782   

Gene Ontology

GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005770 C:late endosome
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0007595 P:lactation
GO:0061088 P:regulation of sequestering of zinc ion
GO:0009636 P:response to toxin
GO:0033189 P:response to vitamin A
GO:0010043 P:response to zinc ion
GO:0055069 P:zinc ion homeostasis

References (3)

[1] “A novel gene involved in zinc transport is deficient in the lethal milk mouse.”  Huang L.et.al.   9354792
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER 
61:	PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL 
121:	YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE 
181:	VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG 
241:	HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 
301:	YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL 
361:	NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT 
421:	CANCQSSSP