TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.4.4.5
Golgi/secretory granule Zn2+ uptake (into Golgi or granules) permease, ZnT7 (Ishihara et al., 2006)

Accession Number:Q8NEW0
Protein Name:Znt7
Length:376
Molecular Weight:41626.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Golgi apparatus1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q8NEW0 Q8NEW0
eggNOG: prNOG07545 COG1230
HEGENOM: HBG317426 HOG000018690
RefSeq: NP_001138356.1    NP_598003.2   
Entrez Gene ID: 148867   
Pfam: PF01545   
OMIM: 611149  gene
KEGG: hsa:148867    hsa:148867   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0000139 C:Golgi membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0031982 C:vesicle
GO:0008324 F:cation transmembrane transporter activity
GO:0032119 P:sequestering of zinc ion

References (14)

[1] “ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus.”  Kirschke C.P.et.al.   12446736
[2] “Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.”  Devergnas S.et.al.   15276077
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[5] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.”  Suzuki T.et.al.   15994300
[8] “ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus.”  Kirschke C.P.et.al.   12446736
[9] “Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.”  Devergnas S.et.al.   15276077
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[12] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.”  Suzuki T.et.al.   15994300

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN 
61:	CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF 
121:	FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN 
181:	GALDQAHGHV DHCHSHEVKH GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH 
241:	ILADTLGSIG VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL 
301:	LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW ILSQTHNIFT 
361:	QAGVRQLYVQ IDFAAM