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2.A.4.4.6
Metal tolerance protein C2 (AtMTPc2) (AtMTP5).  Forms a large, active, heteromeric complex with MTP12 in the golgi and pumps Zn2+ into this organelle (Fujiwara et al. 2015).  MTP12 has 798 aas and 14 TMSs.  Its UniProt acc # is A0A0A8IL98. In Citrus sinensis, expression is induced by Zn2+ in roots (Fu et al. 2017).

Accession Number:Q6ICY4
Protein Name:Metal tolerance protein C2
Length:393
Molecular Weight:43815.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q6ICY4
eggNOG: COG1230
HEGENOM: HOG000006106
Entrez Gene ID: 820384   
Pfam: PF01545   
KEGG: ath:AT3G12100   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005774 C:vacuolar membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0009624 P:response to nematode

References (4)

[1] “Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones.”  Kaneko T.et.al.   10907853
[2] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.”  Salanoubat M.et.al.   11130713
[3] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[4] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERSISFNPR GDNELPDDRS SDVGYAANDR RLAYSRSFQQ SHGPRTPAVT EAAKPFLDRT 
61:	VSSIDMPPDI YSVDGSDVFF GEGKDVDMAK VSVLEMVWEV FGVVTSGNRQ MKRLFLLIAL 
121:	NVLYSTTELS IGIFTGRVGL VSDAFHLTFG CGLLTFSLFA MATSRKKPDH AYSYGYKRLE 
181:	VLSAFTNALF LMFMSFSLAV EALHAFIQDE SEHKHYLIVS AVTNLLVNLL GVWFFRNYAR 
241:	VNIAYRKAED MNYHSVCLHV ISDSIRSAGL ILASWLLSLG VENAEVLCLG LVSVTVFMLV 
301:	MPLFKATGGV LLQMAPPNIP SSALSKCLRQ ITSREDVTEV LQARFWEVVP GHTVGSLRLQ 
361:	VKSGIDERPL LQYVYDVYHD LGVQDLTLQT DYT