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2.A.4.7.4
Putative magnetosome membrane iron transporter, MamM.  Forms a heterodimeric stable complex with MamB which it stabilizes.  MamB; see 2.A.4.7.3) also interacts with other proteins including the PDZ1 domain of MamE (Q6NE61).  Both MamB and MamM are essential for magnetite biomineralization and are involved in several steps in magnetosome formation, but only MamB is essential for formation of magnetosome membrane vesicles (Uebe et al. 2011).  Implicated in iron uptake due to homology with other CDF transporters. Most CDF proteins contain two domains, the cation transporting transmembrane domain and the regulatory cytoplasmic C-terminal domain (CTD). A MamM M250P mutation that is synonymous with the disease-related mutation L349P of the human CDF protein, ZnT-10 causes severe structural changes in its CTD, resulting in abnormally reduced function.Thus, the CTD fold is critical for the CDF proteins' proper function and suggest that the CDF cytoplasmic domain is a CDF regulatory element (Barber-Zucker et al. 2016).

Accession Number:Q6NE57
Protein Name:Magnetosome protein MamM
Length:318
Molecular Weight:34485.00
Species:Magnetospirillum gryphiswaldense [55518]
Number of TMSs:5
Substrate Fe2+

Cross database links:

Structure:
3W5X   3W5Y   3W5Z   3W60   3W61   3W62   3W63   3W64   3W65   3W66   [...more]

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRKSGCAVCS RSIGWVGLAV STVLMVMKAF VGLIGGSQAM LADAMYSLKD MLNALMVIIG 
61:	TTISSKPLDA EHPYGHGKVE FILSMVVSVV FIVLTGYLLV HAVQILLDES LHRTPHLIVL 
121:	WAALVSIGVN VGMYFYSRCV AIETNSPLIK TMAKHHHGDA TASGAVALGI IGAHYLNMPW 
181:	IDPAVALWET IDLLLLGKVV FMDAYRGLMD HTAGEAVQNR IVEAAERVPG VRGVIHLRAR 
241:	YVGQDIWADM IIGVDPENTV EQAHEICEAV QAAVCGKIRR IESLHVSAEA REIGDTTKPS 
301:	FSDQPLSFDE VMLSKVDN