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2.A.40.1.3
Putative pyrimidine permease, RutG (Loh et al., 2006; Kim et al. 2010).

Accession Number:P75892
Protein Name:RutG
Length:442
Molecular Weight:45557.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Pyrimidines

Cross database links:

Genevestigator: P75892
EchoBASE: EB3613
EcoGene: EG13853
eggNOG: COG2233
HEGENOM: HBG470187
RefSeq: AP_001637.1    NP_415526.4   
Entrez Gene ID: 946589   
Pfam: PF00860   
BioCyc: EcoCyc:B1006-MONOMER    ECOL168927:B1006-MONOMER   
KEGG: ecj:JW5137    eco:b1006   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (5)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[5] “A previously undescribed pathway for pyrimidine catabolism.”  Loh K.D.et.al.   16540542

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMFGFPHWQ LKSTSTESGV VAPDERLPFA QTAVMGVQHA VAMFGATVLM PILMGLDPNL 
61:	SILMSGIGTL LFFFITGGRV PSYLGSSAAF VGVVIAATGF NGQGINPNIS IALGGIIACG 
121:	LVYTVIGLVV MKIGTRWIER LMPPVVTGAV VMAIGLNLAP IAVKSVSASA FDSWMAVMTV 
181:	LCIGLVAVFT RGMIQRLLIL VGLIVACLLY GVMTNVLGLG KAVDFTLVSH AAWFGLPHFS 
241:	TPAFNGQAMM LIAPVAVILV AENLGHLKAV AGMTGRNMDP YMGRAFVGDG LATMLSGSVG 
301:	GSGVTTYAEN IGVMAVTKVY STLVFVAAAV IAMLLGFSPK FGALIHTIPA AVIGGASIVV 
361:	FGLIAVAGAR IWVQNRVDLS QNGNLIMVAV TLVLGAGDFA LTLGGFTLGG IGTATFGAIL 
421:	LNALLSRKLV DVPPPEVVHQ EP