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2.A.40.6.1
L-ascorbate:Na+ symporter, SVCT1. (L-ascorbate:Na+= 1:2; Mackenzie et al., 2008). Iron regulates SVCT1 in human intestinal Caco-2 cells (Scheers and Sandberg, 2011).

Accession Number:Q9WTW7
Protein Name:SLC23A1 aka SVCT1
Length:604
Molecular Weight:65263.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-ascorbate, Na+

Cross database links:

Genevestigator: Q9WTW7
eggNOG: maNOG13439
RefSeq: NP_059011.1   
Entrez Gene ID: 50621   
Pfam: PF00860   
KEGG: rno:50621   

Gene Ontology

GO:0009925 C:basal plasma membrane
GO:0005903 C:brush border
GO:0005737 C:cytoplasm
GO:0005887 C:integral to plasma membrane
GO:0008520 F:L-ascorbate:sodium symporter activity
GO:0015229 F:L-ascorbic acid transporter activity
GO:0015882 P:L-ascorbic acid transport
GO:0006814 P:sodium ion transport

References (2)

[1] “A family of mammalian Na+-dependent L-ascorbic acid transporters.”  Tsukaguchi H.et.al.   10331392
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKAQEDPGSS KQHECPDSAG TSTRDQQAPL PAEPKFDMLY KIEDVPPWYL CILLGFQHYL 
61:	TCFSGTIAVP FLLAEALCVG RDQHMISQLI GTIFTCVGIT TLIQTTVGIR LPLFQASAFA 
121:	FLVPAKAILA LERWKCPPEE EIYGNWSMPL NTSHIWHPRI REVQGAIMVS SVVEVVIGLL 
181:	GLPGALLSYI GPLTVTPTVS LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF 
241:	LLPVYRWGKG LTLFRIQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR 
301:	GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA RLAGAPPPPV 
361:	HAINRGIFTE GVCCIIAGLL GTGNGSTSSS PNIGVLGITK VGSRRVVQYG AGIMLILGAI 
421:	GKFTALFASL PDPILGGMFC TLFGMITAVG LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN 
481:	YLDSNPGAIN TGVPEVDQIL TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA 
541:	NSETLASLKS YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK TENQPAVLED APDNTETGSV 
601:	CTKV