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2.A.40.6.2
Ca2+/Mg2+-dependent L-ascorbate:Na+ symporter, SVCT2; Na+:ascorbate = 2:1; binding order: Na+, ascorbate, Na+ (Na+ increases the affinity for ascorbate; Ca2+/Mg2+ are required for function) (Godoy et al., 2007; Bürzle et al. 2013).

Accession Number:Q9UGH3
Protein Name:SVCT2 aka SLC23A2
Length:650
Molecular Weight:70337.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, Mg2+, Na+, L-ascorbate

Cross database links:

COG2233
Genevestigator: Q9UGH3 Q9UGH3
HEGENOM: HBG713856
RefSeq: NP_005107.4    NP_976072.1   
Entrez Gene ID: 9962   
Pfam: PF00860   
OMIM: 603791  gene
KEGG: hsa:9962    hsa:9962   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0070890 F:sodium-dependent L-ascorbate transmembrane ...
GO:0008523 F:sodium-dependent multivitamin transmembrane...
GO:0019852 P:L-ascorbic acid metabolic process
GO:0015993 P:molecular hydrogen transport
GO:0015851 P:nucleobase transport
GO:0006139 P:nucleobase, nucleoside, nucleotide and nucl...
GO:0006814 P:sodium ion transport
GO:0070904 P:transepithelial L-ascorbic acid transport
GO:0009925 C:basal plasma membrane
GO:0005737 C:cytoplasm
GO:0008520 F:L-ascorbate:sodium symporter activity
GO:0070890 F:sodium-dependent L-ascorbate transmembrane transporter activity
GO:0008523 F:sodium-dependent multivitamin transmembrane transporter activity
GO:0006139 P:nucleobase-containing compound metabolic process
GO:0006979 P:response to oxidative stress

References (20)

[1] “Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.”  Faaland C.A.et.al.   9804989
[2] “Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.”  Rajan D.P.et.al.   10471399
[3] “Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.”  Daruwala R.C.et.al.   10556521
[4] “A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.”  Hogue D.L.et.al.   10395795
[5] “Vitamin C transport systems of mammalian cells.”  Liang W.J.et.al.   11396616
[6] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[7] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”  Nakajima D.et.al.   12168954
[8] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[11] “Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.”  Faaland C.A.et.al.   9804989
[12] “Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.”  Rajan D.P.et.al.   10471399
[13] “Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.”  Daruwala R.C.et.al.   10556521
[14] “A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.”  Hogue D.L.et.al.   10395795
[15] “Vitamin C transport systems of mammalian cells.”  Liang W.J.et.al.   11396616
[16] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[17] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”  Nakajima D.et.al.   12168954
[18] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[19] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[20] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD NEDTELMAIY 
61:	TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY LCIFLGLQHY LTCFSGTIAV 
121:	PFLLADAMCV GYDQWATSQL IGTIFFCVGI TTLLQTTFGC RLPLFQASAF AFLAPARAIL 
181:	SLDKWKCNTT DVSVANGTAE LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK 
241:	YIGPLTITPT VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK 
301:	KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD ARQGVLLVAP 
361:	WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA CARLSCAPPP PIHAINRGIF 
421:	VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI TKVGSRRVIQ CGAALMLALG MIGKFSALFA 
481:	SLPDPVLGAL FCTLFGMITA VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV 
541:	TGITGIDQVL NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES 
601:	YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG