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2.A.42.1.1
Tyrosine permease

Accession Number:P0AAD4
Protein Name:Tyrosine-specific transport protein TyrP aka B1907
Length:403
Molecular Weight:42819.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate tyrosine

Cross database links:

Genevestigator: P0AAD4
EchoBASE: EB1034
EcoGene: EG11041
eggNOG: COG0814
HEGENOM: HBG482321
DIP: DIP-48105N
RefSeq: AP_002525.1    NP_416420.1   
Entrez Gene ID: 946412   
Pfam: PF03222   
BioCyc: EcoCyc:TYRP-MONOMER    ECOL168927:B1907-MONOMER   
KEGG: ecj:JW1895    eco:b1907   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006865 P:amino acid transport

References (5)

[1] “DNA sequence of the gene (tyrP) encoding the tyrosine-specific transport system of Escherichia coli.”  Wookey P.J.et.al.   3049553
[2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNRTLGSVF IVAGTTIGAG MLAMPLAAAG VGFSVTLILL IGLWALMCYT ALLLLEVYQH 
61:	VPADTGLGTL AKRYLGRYGQ WLTGFSMMFL MYALTAAYIS GAGELLASSI SDWTGISMSA 
121:	TAGVLLFTFV AGGVVCVGTS LVDLFNRFLF SAKIIFLVVM LVLLLPHIHK VNLLTLPLQQ 
181:	GLALSAIPVI FTSFGFHGSV PSIVSYMDGN IRKLRWVFII GSAIPLVAYI FWQVATLGSI 
241:	DSTTFMGLLA NHAGLNGLLQ ALREMVASPH VELAVHLFAD LALATSFLGV ALGLFDYLAD 
301:	LFQRSNTVGG RLQTGAITFL PPLAFALFYP RGFVMALGYA GVALAVLALI IPSLLTWQSR 
361:	KHNPQAGYRV KGGRPALVVV FLCGIAVIGV QFLIAAGLLP EVG