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2.A.42.2.2
Threonine/Serine permease

Accession Number:P0AAD8
Protein Name:Threonine/serine transporter TdcC aka B3116
Length:443
Molecular Weight:48879.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Serine, Threonine

Cross database links:

Genevestigator: P0AAD8
EchoBASE: EB0984
EcoGene: EG10991
eggNOG: COG0814
HEGENOM: HBG296888
DIP: DIP-48056N
RefSeq: AP_003664.1    NP_417586.1   
Entrez Gene ID: 947629   
Pfam: PF03222   
BioCyc: EcoCyc:TDCC-MONOMER    ECOL168927:B3116-MONOMER   
KEGG: ecj:JW3087    eco:b3116   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport

References (6)

[1] “The complete nucleotide sequence of the tdc region of Escherichia coli.”  Schweizer H.et.al.   2660107
[2] “Molecular characterization of the tdc operon of Escherichia coli K-12.”  Goss T.J.et.al.   3053659
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Isolation and characterization of an Escherichia coli mutant lacking the major serine transporter, and cloning of a serine transporter gene.”  Ogawa W.et.al.   9498571
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTSDSIVSS QTKQSSWRKS DTTWTLGLFG TAIGAGVLFF PIRAGFGGLI PILLMLVLAY 
61:	PIAFYCHRAL ARLCLSGSNP SGNITETVEE HFGKTGGVVI TFLYFFAICP LLWIYGVTIT 
121:	NTFMTFWENQ LGFAPLNRGF VALFLLLLMA FVIWFGKDLM VKVMSYLVWP FIASLVLISL 
181:	SLIPYWNSAV IDQVDLGSLS LTGHDGILIT VWLGISIMVF SFNFSPIVSS FVVSKREEYE 
241:	KDFGRDFTER KCSQIISRAS MLMVAVVMFF AFSCLFTLSP ANMAEAKAQN IPVLSYLANH 
301:	FASMTGTKTT FAITLEYAAS IIALVAIFKS FFGHYLGTLE GLNGLVLKFG YKGDKTKVSL 
361:	GKLNTISMIF IMGSTWVVAY ANPNILDLIE AMGAPIIASL LCLLPMYAIR KAPSLAKYRG 
421:	RLDNVFVTVI GLLTILNIVY KLF