2.A.46 The Benzoate:H+ Symporter (BenE) Family
The BenE family contains only two sequenced members, the benzoate permeases of Acinetobacter calcoaceticus and a putative benzoate permease of E. coli. These proteins are about 400 residues in length and probably span the membrane 12 times. They exhibit about 30% identity to each other and limited sequence similarity to members of the aromatic acid:H+symporter (AAHS) family (2.A.1.15) of the major facilitator superfamily (MFS). However the degree of similarity with the latter proteins is insufficient to establish homology. Thus, in spite of the sequence similarity and their similar substrate specificities, the BenE family must be considered separately.
The generalized transport reaction catalyzed by BenE of A. calcoaceticus is:
Benzoate (out) + H+ (out) → benzoate (in) + H+ (in).