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2.A.47.1.16
Solute carrier family 13 member 1 (Renal and intestinal sodium/sulfate cotransporter) (Na+/sulfate cotransporter) (hNaSi-1).  Also transports thiosulfate and selenium.  It is inhibited by many di- and tri-valent organic and inorganic anions (Markovich 2013).

Accession Number:Q9BZW2
Protein Name:Solute carrier family 13 member 1
Length:595
Molecular Weight:66134.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Sfulate, Thiosulfate, Selenium, anions

Cross database links:

Genevestigator: Q9BZW2
eggNOG: COG0471
HEGENOM: HOG000278432
Entrez Gene ID: 6561   
Pfam: PF00939   
Drugbank: Drugbank Link   
KEGG: hsa:6561   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015382 F:sodium:sulfate symporter activity
GO:0055085 P:transmembrane transport

References (2)

[1] “The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization.”  Lee A.et.al.   11161786
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL 
61:	LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP 
121:	AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG 
181:	LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT 
241:	CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW 
301:	IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL 
361:	WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP 
421:	LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM 
481:	VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF 
541:	SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP