TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameOrganismal TypeExample
2.A.47.1.1
Anion transporter of unknown specificity
Archaea
Anion transporter of Methanospirillum hungatei (Q2FMC1)
2.A.47.1.2
Renal sodium:sulfate cotransporter (Ssc) (NaS1-1) (also transports thiosulfate and selenate) (Li and Pajor, 2003)
Animals
Ssc of Rattus norvegicus
2.A.47.1.3
The brush boarder intestinal and renal electrogenic, Na+-dependent, low affinity (0.1-4.0mM), dicarboxylate (succinate, fumarate, malate, α-ketoglutarate, oxaloacetate, L- and D-glutamate, and citrate):H+ cotransporter, NaDC-1 or SDCT1.
Animals
NaDC-1 or SDCT1 of Rattus norvegicus (O35055)
2.A.47.1.4
The basolateral intestinal and renal electrogenic, Na+-dependent high affinity (2-50µM) dicarboxylate:(Na+)3 cotransporter (NaDC-3) (substrate range similar to that of NDC-1 except that tricarboxylates are transported with very low affinity). Na+:succinate = 3:1. Also transports N-acetyl-L-aspartate, an abundant amino acid in the nervous system (Yodoya et al., 2006).
Animals
NaDC-3 of Rattus norvegicus
2.A.47.1.5
Basolateral Na+: di- and tricarboxylate (succinate cis-aconitate, citrate, etc.) cotransporter, fNaDC-3
Animals
fNaDC-3 of Pseudopleuronectes americanus (the winter flounder)
2.A.47.1.6
The tonoplast dicarboxylate (malate) transporter, AttDT (Kovermann et al., 2007).
Plants
AttDT of malate:Na+ symporter of Arabidopsis thaliana
2.A.47.1.7
Low affinity dicarboxylate:Na+ symporter, NaDC1 (INDY1) (relative affinities: succinate > fumarate > α-ketoglutarate > malate > lactate > maleate) (Fei et al., 2003)
Animals
NaDC1 of Caenorhabditis elegans
2.A.47.1.8
High affinity dicarboxylate:Na+ symporter, NaDC2 (INDY2) (relative affinities: fumarate > malate > α-ketoglutarate > maleate > succinate > lactate) (Fei et al., 2003)
Animals
NaDC2 of Caenorhabditis elegans
2.A.47.1.9
Na+-coupled citrate transporter (NaCT) (Km=18μM) (also may transport dicarboxylates and other tricarboxylates with lower affinity) (Inoue et al., 2002). Na+:citrate = 3-4:1 (Wada et al., 2006).
Animals
NaCT of Homo sapiens
2.A.47.1.10
Cation-independent, electroneutral tri- and di-carboxylate transporter with a preference for tricarboxylates, Indy (I'm not dead yet) [When Indy is mutated flies live about twice as long as wild type] (Inoue et al., 2002)
Animals
Indy of Drosophila melanogaster (Q9VVT2)
2.A.47.1.11
The Na+:dicarboxylate (2:1) symporter, SdcS (catalyzes succinate:succinate antiport as well as electroneutral symport in reconstituted proteoliposomes (Hall and Pajor, 2007; Joshi and Pajor, 2009)

Bacteria

SdcS of Staphylococcus aureus (Q2FFH9)
2.A.47.1.12
The aerobic dicarboxylate (succinate, fumarate, malate) transporter, DcsT (Teramoto et al., 2008).
Bacteria
DcsT of Corynebacterium glutamicum (A4QAL6)
2.A.47.1.13

The Na+-coupled dicarboxylate transporter, SdcL (transports aspartate, α-ketoglutarate and oxaloacetate with low affinity) (Strickler et al., 2009).

Bacteria

SdcL of Bacillus licheniformis (Q65NC0)
2.A.47.2.1
Inorganic phosphate transporter, Pho87
Yeast
Pho87 of Saccharomyces cerevisiae
2.A.47.2.2
Vacuolar low affinity phosphate transporter, Pho91 (Estrella et al., 2008)
Yeast
Pho91 of Saccharomyces cerevisiae (P27514)
2.A.47.3.1
2-oxoglutarate:malate antiporter (SodiTl)
Plant chloroplasts
SodiTl of Spinacia oleracea
2.A.47.3.2
Citrate:succinate antiporter
Bacteria
CitT of E. coli (P0AE74)
2.A.47.3.3
L-tartrate:succinate antiporter, TtdT (YgjE). (also takes up both L-tartrate and succinate; does not transport D-tartrate) (Kim and Unden, 2007).
Bacteria
TtdT (YgjE) of E. coli (P39414)
2.A.47.3.4
The pmf-dependent citrate uptake system, Cit1 (Urbany and Neuhaus, 2008)
Bacteria
Cit1 of Erwinia carotovora subsp. atroseptica (Q6D017)
2.A.47.4.1
Sulfur-deprivation response protein
Cyanobacteria
SdrP of Synechocystis
2.A.47.4.2
Antimonite resistance protein (inducible by both arsenite and antimonite although arsenite resistance was not detected)
Archaea
ArsB of Halobacterium spNRC-1 (AAG20642)
2.A.47.4.3

The Na+/sulfate symporter, Slt1 (Pootakham et al., 2010)

Algae

Slt1 of Chlamydomonas reinhardtii (A8IJF8)
2.A.47.4.4

The Na+/sulfate symporter, Slt2 (Pootakham et al., 2010)

Algae

Slt2 of Chlamydomonas reinhardtii (A8IHV5)
2.A.47.5.1
Hypothetical Na+ cotransporter, Orfl
Archaea
Orfl of Methanococcus jannaschii