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TCID	Name	Organismal Type	Example
2.A.5.1.1	High affinity zinc uptake transporter, Zrt1	Yeast, animals, plants	Zrt1 of Saccharomyces cerevisiae
2.A.5.1.2	Iron regulated Fit1-mediated plasma membrane high affinity Fe²⁺ uptake transporter, Irt1 (also takes up Co²⁺, Mn²⁺, Zn²⁺ and possibly Cd²⁺ and Fe²⁺) (Korshunova et al., 1999; Schaaf et al., 2006)	Plants, animals, yeast	Irt1 of Arabidopsis thaliana
2.A.5.1.3	Zinc/iron uptake transporter, Zip1 (Grass et al., 2005; Grotz et al., 1998)	Plants	Zip1 of Arabidopsis thaliana (O81123)
2.A.5.1.4	Iron-regulated Fit1-mediated (coregulated with Irt1) vacuolar high-affinity Fe²⁺ efflux (from the vacuole into the cytoplasm) transporter, Irt2 (also transports Zn²⁺ (Schaaf et al., 2006)	Plants	Irt2 of Arabidopsis thaliana (O81850)
2.A.5.2.1	Golgi Mn² homeostasis protein (probably pumps Mn² into cytoplasm), ATX2 (Eide, D.J, 1998)	Yeast	ATX2 of Saccharomyces cerevisiae
2.A.5.3.1	Growth arrest-inducible protein	Animals	Growth arrest-inducible protein of Homo sapiens
2.A.5.3.2	Zn²⁺ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn²⁺) (Gaither and Eide, 2000).	Animals	Zip1 of Homo sapiens (Q9NY26)
2.A.5.3.3	Zn²⁺ uptake transporter, Zip3 (poorly expressed; involved in Zn²⁺ homeostasis) (Dufner-Beattie et al., 2003).	Animals	Zip3 of Homo sapiens (Q9BRY0)
2.A.5.4.1	Zip4 Zn²⁺ uptake transporter (Acrodermatitis enteropathica zinc-deficiency disease protein) (Dufner-Beattie et al., 2003)	Animals	Zip4 of Homo sapiens
2.A.5.4.2	Zinc transporter, LIV1 (essential for the nuclear localization of the zinc-finger protein Snail, a master regulator of the epithelial-mesenchymal transition in zebrafish gastrulation) (Yamashita et al., 2004)	Animals	LIV1 in Danio rerio (Q6L8F3)
2.A.5.4.3	Zip7 golgi Zn²⁺ uptake (into the cytoplasm) transporter (Ke4, Slc39a7) (Huang et al., 2005). This protein can substitute for Iar1, the indole acetic acid-alanine resistance protein, of A. thaliana (Lasswell et al., 2000)	Animals	Ke4 of Mus musculus (Q92504)
2.A.5.4.4	Bidirectional endoplasmic reticular Zn²⁺ transporter, Yke4 (346 aas; Kumanovics et al., 2006)	Yeast	Yke4 (YIL023c) of Saccharomyces cerevisiae (P40544)
2.A.5.4.5	Zip14 Zn²⁺/Fe²⁺ uptake transporter (mobilized to the sinusoidal membrane of the hepatocyte during acute inflammation). May also transport other divalent cations including Cd²⁺.	Animals	Zip14 of Homo sapiens (Q6ZME8)
2.A.5.4.6	Zinc transporter, Zip10 (plays an essential role in the migratory activity of highly metastatic breast cancer cells) (Kagara et al., 2007)	Animals	Zip10 of Homo sapiens (Q9ULF5)
2.A.5.4.7	The indole acetic acid-alanine resistance protein 1, Iar1 (Lasswell et al., 2000)	Plants	Iar1 of Arabidopsis thaliana (Q9M647)
2.A.5.4.8	The divalent cation (M²⁺): bicarbonate (HCO₃^-) transporter (M²⁺:HCO₃^- = 1:2). Transports Cd²⁺ and Zn²⁺, and probably Cu²⁺, Pb²⁺, and Hg²⁺ (based on competitive inhibition studies (Liu et al., 2008))	Animals	Zip8 of Mus musculus (Q91W10)
2.A.5.4.9	Probable Zn²⁺ transporter, Zip13 (SLC39A13). Mice deficient in Zn transporter Slc39a13/Zip13 show changes in bone, teeth and connective tissue reminiscent of the clinical spectrum of human Ehlers-Danlos syndrome (EDS) (Fukada et al., 2008).	Animals	Zip13 of Mus musculus (Q8BZH0)
2.a.5.4.10	Zn²⁺ transporter, Zip5 (540aas; 1+3+3 TMSs; processed to a 3+3 TMS protein) (Basolateral membrane; carries out serosal to mucosal transport)	Animals	Zip5 of Homo sapiens (Q6ZMH5)
2.A.5.5.1	Broad specificity heavy metal divalent cation uptake transporter, ZupT (Fe²⁺, Co²⁺, Mn²⁺, Cd²⁺ and Zn²⁺ are transported) (Grass et al., 2005). Point mutations change the specificity and kinetics of metal uptake (Taudte and Grass, 2010).	Bacteria	ZupT of E. coli (P0A8H3)
2.A.5.6.1	The Fe²⁺ transporter, Lit1, required for intracellular growth and virulence of Leishmania (Huynh and Andrews, 2007)	Protozoans	Lit1 of Leishmania major (Q4Q5V1)
2.A.5.7.1	Zip family member, ZIP9 (SLC39A9) (307aas; 8 TMSs)	Animals	SLC39A9 of Homo sapiens (Q9NUM3)