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2.A.53.2.3
Intestinal down-regulated in adenoma (DRA) protein; HCO3-/Cl- antiporter, SLC26a3 (responsible for congenital chloride-losing diarrhea in humans) (Schweinfest et al., 2006). DRA has 12 putative TMSs and a C-terminal STAS domain required for function and activation of CFTR by DRA (Dorwart et al., 2008). Catalyzes 2Cl-/1HCO3- antiport, Cl-/OH- exchange and sulfate transport (Shcheynikov et al., 2006; Moseley et al., 1999). Loss in mice impairs mucosal HCO3- secretion (Xiao et al., 2012).

Accession Number:Q9WVC8
Protein Name:SLC26A3 aka DRA
Length:757
Molecular Weight:83590.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate bicarbonate, Cl-

Cross database links:

Genevestigator: Q9WVC8
HEGENOM: HBG446299
RefSeq: NP_067328.1   
Entrez Gene ID: 13487   
Pfam: PF01740    PF00916   
KEGG: mmu:13487   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0008271 F:secondary active sulfate transmembrane tran...
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger.”  Melvin J.E.et.al.   10428871
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIEAIGNQYV VARPVYSTKT FGEEFKKTHR HHKTFLDHLK GCCSCSSQKA KKIALSLFPI 
61:	ASWLPAYKIK EWLLSDIVSG ISTGLVAVLQ GLAFALLVNI PPAYGLYAAF FPVITYFFLG 
121:	TSRHISVGPF PVLSMMVGVV VTRVVSDPNA SSELSSSSTE NDSFIEEKVM VAASVTVLSG 
181:	IIQLLLGVLQ VGFVVIYLSE SLISGFTTAA AIHVLVSQLK FMLQLPVPAY SDPFSIFKVL 
241:	ESVFTQIQKT NIADLVTSVI ILVVVFVFKE INQRYRSKLP VPIPIELIMT VIATGVSYGC 
301:	NFEDRFGVAV VGNMSLGFQP PITPSVEVFQ DTIGDSFGIA IVGFAVAFSV ASVYSLKYDY 
361:	PIDGNQELIA LGVSNIFTGA FKGFAGSTAL SRSGVQESTG GKTQVAGLLS AVIVLIVIVA 
421:	IGFLLQPLQK SVLAALALGN LKGMLMQFAE IGRLWKKDKY DCLIWIMTFI FAIVLGLGLG 
481:	LAASVAFQLL TIVFRTQFPK CSTLANVGRS NIYKNKKNYA EVYEPEGVKI FRCPSPIYFA 
541:	NIGFFKQKLI DAVGFSPLRI LRKRNKALKK IRKLQKRGLI QMTPKGFICT SDGFKDSDEE 
601:	LDNNQIEELD QPINTTDLPF DIDWNGDLPL NITIPKISLH SLILDFSAVS FLDVSSMRGL 
661:	RTILQEFIRI KVDVYIVGTD DDFIDKLARC EFFDDEVTDS IFFLTIHDAI LHILMKKDYS 
721:	TSKFNSSQEK ERKFDFTINT NGGLRNRECQ VPVETKF