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2.A.53.2.7
The human Slc26a6 anion exchanger (transports sulfate, formate, oxalate, chloride and bicarbonate in antiport with any one of these anions) (Jiang et al., 2002). However, Cl- and HSO4- are transported slowly; Cl-/HCO3-, Cl-/OH- and Cl-:oxalate exchange reactions are electroneutral (Chernova et al., 2005). (The oxalate nephrolithiasis gene; Clark et al., 2008). Catalyzes 1Cl-/2HCO3- antiport (Shcheynikov et al., 2006; Walker et al., 2010).

Accession Number:Q9BXS9
Protein Name:SLC26A6 aka Pendrin L1
Length:759
Molecular Weight:82967.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Sulfate, formate, Oxalate, Cl-, bicarbonate, Hydroxide, Hydrogen sulfate

Cross database links:

COG0659
Genevestigator: Q9BXS9 Q9BXS9
HEGENOM: HBG446299 HOG000006546
RefSeq: NP_075062.2    NP_599025.2    NP_602298.2   
Entrez Gene ID: 65010   
Pfam: PF01740    PF00916   
OMIM: 610068  gene
KEGG: hsa:65010   

Gene Ontology

GO:0008271 F:secondary active sulfate transmembrane tran...
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0015301 F:anion:anion antiporter activity
GO:0015108 F:chloride transmembrane transporter activity
GO:0015499 F:formate transmembrane transporter activity
GO:0008271 F:secondary active sulfate transmembrane transporter activity
GO:0015701 P:bicarbonate transport
GO:0006811 P:ion transport

References (7)

[1] “Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family.”  Waldegger S.et.al.   11247665
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[4] “Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family.”  Waldegger S.et.al.   11247665
[5] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA PRTHQWRTWL 
61:	QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV AIMQLPQGLA YALLAGLPPV 
121:	FGLYSSFYPV FIYFLFGTSR HISVGTFAVM SVMVGSVTES LAPQALNDSM INETARDAAR 
181:	VQVASTLSVL VGLFQVGLGL IHFGFVVTYL SEPLVRGYTT AAAVQVFVSQ LKYVFGLHLS 
241:	SHSGPLSLIY TVLEVCWKLP QSKVGTVVTA AVAGVVLVVV KLLNDKLQQQ LPMPIPGELL 
301:	TLIGATGISY GMGLKHRFEV DVVGNIPAGL VPPVAPNTQL FSKLVGSAFT IAVVGFAIAI 
361:	SLGKIFALRH GYRVDSNQEL VALGLSNLIG GIFQCFPVSC SMSRSLVQES TGGNSQVAGA 
421:	ISSLFILLII VKLGELFHDL PKAVLAAIII VNLKGMLRQL SDMRSLWKAN RADLLIWLVT 
481:	FTATILLNLD LGLVVAVIFS LLLVVVRTQM PHYSVLGQVP DTDIYRDVAE YSEAKEVRGV 
541:	KVFRSSATVY FANAEFYSDA LKQRCGVDVD FLISQKKKLL KKQEQLKLKQ LQKEEKLRKQ 
601:	AASPKGASVS INVNTSLEDM RSNNVEDCKM MQVSSGDKME DATANGQEDS KAPDGSTLKA 
661:	LGLPQPDFHS LILDLGALSF VDTVCLKSLK NIFHDFREIE VEVYMAACHS PVVSQLEAGH 
721:	FFDASITKKH LFASVHDAVT FALQHPRPVP DSPVSVTRL