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2.A.53.2.8
The mouse Slc26a6 anion exchanger (same substrate specificity as its human orthologue (2.A.53.2.7)), but Cl- and HSO4- are transported rapidly. Moreover, although Cl-/HCO3- and Cl-/OH- exchange reactions are electroneutral, Cl-:oxalate exchange is electrogenic (Chernova et al., 2005). Also catalyzes Cl-:formate exchange (Knauf et al., 2001).

Accession Number:Q8K142
Protein Name:Solute carrier family 26, member 6
Length:735
Molecular Weight:80496.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-, Hydrogen sulfate, Sulfate, formate, Oxalate, bicarbonate, Hydroxide

Cross database links:

Genevestigator: Q8K142
RefSeq: NP_599252.2   
Entrez Gene ID: 171429   
Pfam: PF01740    PF00916   
KEGG: mmu:171429   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015380 F:anion exchanger activity
GO:0015108 F:chloride transmembrane transporter activity
GO:0015499 F:formate transmembrane transporter activity
GO:0008271 F:secondary active sulfate transmembrane tran...
GO:0015701 P:bicarbonate transport
GO:0006821 P:chloride transport
GO:0015724 P:formate transport
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELQRRDYHV ERPLLNQEQL EDLGHWGPAA KTHQWRTWFR CSRARAHSLL LQHVPVLGWL 
61:	PRYPVREWLL GDLLSGLSVA IMQLPQGLAY ALLAGLPPMF GLYSSFYPVF IYFLFGTSRH 
121:	ISVGTFAVMS VMVGSVTESL TADKAFVQGL NATADDARVQ VAYTLSFLVG LFQVGLGLVH 
181:	FGFVVTYLSE PLVRSYTTAA SVQVLVSQLK YVFGIKLSSH SGPLSVIYTV LEVCAQLPET 
241:	VPGTVVTAIV AGVALVLVKL LNEKLHRRLP LPIPGELLTL IGATGISYGV KLNDRFKVDV 
301:	VGNITTGLIP PVAPKTELFA TLVGNAFAIA VVGFAIAISL GKIFALRHGY RVDSNQELVA 
361:	LGLSNLIGGF FQCFPVSCSM SRSLVQESTG GNTQVAGAVS SLFILLIIVK LGELFRDLPK 
421:	AVLAAVIIVN LKGMMKQFSD ICSLWKANRV DLLIWLVTFV ATILLNLDIG LAVSIVFSLL 
481:	LVVVRMQLPH YSVLGQVPDT DIYRDVAEYS GAKEVPGVKV FRSSATLYFA NAELYSDSLK 
541:	EKCGVDVDRL ITQKKKRIKK QEMKLKRMKK AKKSQKQDAS SKISSVSVNV NTNLEDVKSN 
601:	DVEGSEAKVH QGEELQDVVS SNQEDAKAPT MTSLKSLGLP QPGFHSLILD LSTLSFVDTV 
661:	CIKSLKNIFR DFREIEVEVY IAACYSPVVA QLEAGHFFDE SITKQHVFAS VHDAVTFALS 
721:	HRKSVPKSPV LATKL