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2.A.54.1.3
Sideroflexin-4 (Breast cancer resistance marker 1)

Accession Number:Q6P4A7
Protein Name:Sideroflexin-4
Length:337
Molecular Weight:37998.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate Fe3+

Cross database links:

Genevestigator: Q6P4A7
eggNOG: NOG315418
HEGENOM: HOG000010305
Entrez Gene ID: 119559   
Pfam: PF03820   
KEGG: hsa:119559   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0043231 C:intracellular membrane-bounded organelle
GO:0031966 C:mitochondrial membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0055072 P:iron ion homeostasis

References (5)

[1] “Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia.”  Zheng H.et.al.   14756423
[2] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[5] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLEQEEETQ PGRLLGRRDA VPAFIEPNVR FWITERQSFI RRFLQWTELL DPTNVFISVE 
61:	SIENSRQLLC TNEDVSSPAS ADQRIQEAWK RSLATVHPDS SNLIPKLFRP AAFLPFMAPT 
121:	VFLSMTPLKG IKSVILPQVF LCAYMAAFNS INGNRSYTCK PLERSLLMAG AVASSTFLGV 
181:	IPQFVQMKYG LTGPWIKRLL PVIFLVQASG MNVYMSRSLE SIKGIAVMDK EGNVLGHSRI 
241:	AGTKAVRETL ASRIVLFGTS ALIPEVFTYF FKRTQYFRKN PGSLWILKLS CTVLAMGLMV 
301:	PFSFSIFPQI GQIQYCSLEE KIQSPTEETE IFYHRGV