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2.A.54.1.6
Sideroflexin-3

Accession Number:Q91V61
Protein Name:Sideroflexin-3
Length:321
Molecular Weight:35406.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate Fe3+

Cross database links:

Genevestigator: Q91V61
eggNOG: NOG283056
HEGENOM: HOG000203440
Entrez Gene ID: 94280   
Pfam: PF03820   
KEGG: mmu:94280   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0005739 C:mitochondrion
GO:0008324 F:cation transmembrane transporter activity
GO:0055072 P:iron ion homeostasis

References (3)

[1] “A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.”  Fleming M.D.et.al.   11274051
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGDLPLNINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG EQLEASRNIV QNYRAGVATP 
61:	GLTEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM TITGCMLTFY RKTPTVVFWQ 
121:	WVNQSFNAIV NYSNRSGDAP ITVQQLGTAY VSATTGAVAT ALGLKSLTKH LPPLVGRFVP 
181:	FAAVAAANCI NIPLMRQREL QVGIPVTDEA GQRLGHSVTA AKQGIFQVVI SRIGMAIPAM 
241:	AIPPVIMNTL EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQRS SIHVTRLEPE 
301:	LRAQIQAQNP SIDVVYYNKG L