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2.A.54.1.8
Sideroflexin 2, SFXN2 of 322 aas and 5 or 6 TMSs in a 1 or 2 + 2 + 2 TMS arrangement.  SFXN2 is involved in mitochondrial iron metabolism and is localized to the mitochondrial inner membrane (Mon et al. 2019). SFXN2-knockout (KO) cells have an increased mitochondrial iron content and decreases in the heme content and heme-dependent enzyme activities. By contrast, the activities of iron-sulfur cluster-dependent enzymes were unchanged. Abnormal iron metabolism impaired mitochondrial respiration in SFXN2-KO cells and accelerated iron-mediated death (Mon et al. 2019).

Accession Number:Q96NB2
Protein Name:Sideroflexin-2
Length:322
Molecular Weight:36232.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV EKSRMGVVPP 
61:	GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM IITGFMLQFY RTMPAVIFWQ 
121:	WVNQSFNALV NYTNRNAASP TSVRQMALSY FTATTTAVAT AVGMNMLTKK APPLVGRWVP 
181:	FAAVAAANCV NIPMMRQQEL IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM 
241:	ILLPVIMERL EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK 
301:	LQDTIKAKYG ELEPYVYFNK GL