TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameOrganismal TypeExample
2.A.56.1.1
Tripartite dicarboxylate:H+ symporter (substrates include: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate and mesaconate) (Forward et al., 1997)
Gram-negative bacteria
DctPQM dicarboxylate transporter of Rhodobacter capsulatus
DctP (R)
DctQ (M, 4 TMS)
DctM (M, 12 TMS)
2.A.56.1.2
The 2,3-diketo-L-gulonate (2,3-DKG) transporter, YiaMNO [2,3-KDG is a breakdown product of L-ascorbate] (Thomas et al., 2006)
Bacteria
YiaMNO of E. coli
YiaM (M, 4 TMSs; most like TauL) (P37674)
YiaN (M, 12 TMSs; most like DctM) (P37675)
YiaO (R, like DctP and TauK) (P37676)
2.A.56.1.3

Sialic acid (N-acetyl neuraminic acid) transporter, SiaTP (Allen et al., 2005; Severi et al., 2005; Johnston et al., 2008)

Bacteria

SiaTP of Haemophilus influenzae
SiaT (a fusion protein equivalent to both DctM and DctQ) (616 aas; 16 TMSs) (P44543)
SiaP (R) (P44544)
2.A.56.1.4

Putative tripartite taurine uptake system, TauKLM (Bruggemann et al., 2004; Denger et al., 2006)

Bacteria

TauKLM of Rhodobacter sphaeroides
TauK (Rsph2615) (R) (Q3IVI6)
TauL (Rsph2614) (M, 4 TMS) (Q3IVI5)
TauM (Rsph2613) (M, 12 TMS) (Q3IVI4)
2.A.56.1.5
The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, Kd=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, Kd=3 μM]) (Thomas et al., 2006)
Bacteria
The 2-ketomonocarboxylate transporter of Rhodobacter capsulatus
M-large (RRC02479)
M-small (RRC02478)
R (RRC01191)
2.A.56.1.6

The putative rhamnogalacturonide transporter (Rodionov et al., 2009)

Proteobacteria

RhiABC of Salmonella typhimurium
RhiA (R) (P43020)
RhiB (M, 4 TMSs) (Q8ZKR9)
RhiC (M, 12 TMSs) (Q8ZKS0)
2.A.56.2.1
Tripartite high affinity ectoine/hydroxyectoine uptake system (Grammann et al., 2002)
Bacteria
TeaABC ectoine transporter of Halomonas elongata
TeaA (R)
TeaB (M, 4 TMS)
TeaC (M, 12 TMS)
2.A.56.3.1
Tripartite glutamate:Na+ symporter (Quintero et al., 2001)
Gram-negative bacteria
GtrABC glutamate:Na+ symporter of Synechocystis strain PCC6803
GtrA (M) (like DctQ)
GtrB (M) (like DctM)
GtrC (R) (like GlnH of E. coli)
2.A.56.3.2
Tripartite 4-chlorobenzoate symporter (also binds and may transport 4-bromo-, 4-iodo-, and 4-fluorobenzoate and with a lower affinity, 3-chlorobenzoate, 2-chlorobenzoate, 4-hydroxybenzoate, 3-hydroxybenzoate, and benzoate) (Chae and Zylstra, 2006)
Gram-negative bacteria
FcbT1/T2/T3 of Comamonas sp. strain DJ-12
FcbT1 (R) (AAF16407)
FcbT2 (M-sm) (AAF16408)
FcbT3 (M-lg) (AAF16409)