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Accession Number: | Q99808 |
Protein Name: | ENT1 aka hENT1 aka SLC29A1 |
Length: | 456 |
Molecular Weight: | 50219.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | Nucleosides |
Cross database links:
Genevestigator: | Q99808 Q99808 |
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eggNOG: | prNOG15273 NOG249415 |
RefSeq: | NP_001071642.1 NP_001071643.1 NP_001071644.1 NP_001071645.1 NP_004946.1 |
Entrez Gene ID: | 2030 |
Pfam: | PF01733 |
Drugbank: | Drugbank Link |
OMIM: |
602193 gene |
KEGG: | hsa:2030 hsa:2030 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0005337
F:nucleoside transmembrane transporter activity
GO:0005515
F:protein binding
GO:0006139
P:nucleobase, nucleoside, nucleotide and nucl...
GO:0015858
P:nucleoside transport
GO:0016324
C:apical plasma membrane
GO:0016323
C:basolateral plasma membrane
GO:0071333
P:cellular response to glucose stimulus
GO:0071456
P:cellular response to hypoxia
GO:0007595
P:lactation
GO:0006139
P:nucleobase-containing compound metabolic process
GO:0060079
P:regulation of excitatory postsynaptic membrane potential
GO:0030431
P:sleep
GO:0015862
P:uridine transport
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References (19)[1] “Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.” Griffiths M.et.al. 8986748 [2] “Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles.” Lum P.Y.et.al. 10755314 [3] “Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity.” Sankar N.et.al. 12384580 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B.et.al. 19349973 [9] “The consensus coding sequences of human breast and colorectal cancers.” Sjoeblom T.et.al. 16959974 [10] “Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.” Griffiths M.et.al. 8986748 [11] “Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles.” Lum P.Y.et.al. 10755314 [12] “Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity.” Sankar N.et.al. 12384580 [13] “Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.” Mangravite L.M.et.al. 12527552 [14] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [15] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS LVTAELSKDA 61: QASAAPAAPL PERNSLSAIF NNVMTLCAML PLLLFTYLNS FLHQRIPQSV RILGSLVAIL 121: LVFLITAILV KVQLDALPFF VITMIKIVLI NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ 181: GLAGFFASVA MICAIASGSE LSESAFGYFI TACAVIILTI ICYLGLPRLE FYRYYQQLKL 241: EGPGEQETKL DLISKGEEPR AGKEESGVSV SNSQPTNESH SIKAILKNIS VLAFSVCFIF 301: TITIGMFPAV TVEVKSSIAG SSTWERYFIP VSCFLTFNIF DWLGRSLTAV FMWPGKDSRW 361: LPSLVLARLV FVPLLLLCNI KPRRYLTVVF EHDAWFIFFM AAFAFSNGYL ASLCMCFGPK 421: KVKPAEAETA GAIMAFFLCL GLALGAVFSF LFRAIV