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2.A.58.1.4
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na+-dependent phosphate cotransporter 2B) (NaPi-2B) (Sodium/phosphate cotransporter 2B) (Na+/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2).  The membrane potential and cation interactions induce large-scale structural rearrangements of the protein (Patti et al. 2016).

Accession Number:O95436
Protein Name:Sodium-dependent phosphate transport protein 2B
Length:690
Molecular Weight:75759.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate phosphate, Na+

Cross database links:

Genevestigator: O95436
eggNOG: COG1283
HEGENOM: HOG000006550
Entrez Gene ID: 10568   
Pfam: PF02690   
KEGG: hsa:10568   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0031526 C:brush border membrane
GO:0005887 C:integral to plasma membrane
GO:0042301 F:phosphate ion binding
GO:0031402 F:sodium ion binding
GO:0015321 F:sodium-dependent phosphate transmembrane transporter activity
GO:0005436 F:sodium:phosphate symporter activity
GO:0007568 P:aging
GO:0030643 P:cellular phosphate ion homeostasis
GO:0001701 P:in utero embryonic development
GO:0032355 P:response to estradiol stimulus
GO:0043627 P:response to estrogen stimulus
GO:0009750 P:response to fructose stimulus

References (8)

[1] “Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine.”  Feild J.A.et.al.   10329428
[2] “Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2).”  Xu H.et.al.   10610722
[3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor.”  Xu H.et.al.   11171583
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).”  Charest A.et.al.   12661006
[8] “Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis.”  Corut A.et.al.   16960801

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL LPSYSTATLI 
61:	DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS 
121:	AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS STSTSIVVSM VSSSLLTVRA 
181:	AIPIIMGANI GTSITNTIVA LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY 
241:	LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK 
301:	IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP 
361:	DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK KTINTDFPFP FAWLTGYLAI 
421:	LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA 
481:	LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI 
541:	PLTVFGLSLA GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL 
601:	KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE AQEGQDVPVK 
661:	APETFDNITI SREAQGEVPA SDSKTECTAL