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2.A.6.6.5
3-hydroxy-3-methylglutaryl (HMG)-CoA reductase

Accession Number:P04035
Protein Name:HMDH aka HMGCR
Length:888
Molecular Weight:97476.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: P04035
eggNOG: prNOG10146
HEGENOM: HBG355150
RefSeq: NP_000850.1    NP_001124468.1   
Entrez Gene ID: 3156   
Pfam: PF00368   
Drugbank: Drugbank Link   
OMIM: 142910  gene+phenotype
BioCyc: MetaCyc:ENSG00000113161-MONOMER   
KEGG: hsa:3156   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005778 C:peroxisomal membrane
GO:0004420 F:hydroxymethylglutaryl-CoA reductase (NADPH)...
GO:0050661 F:NADP or NADPH binding
GO:0006695 P:cholesterol biosynthetic process
GO:0015936 P:coenzyme A metabolic process
GO:0008354 P:germ cell migration
GO:0008406 P:gonad development
GO:0008299 P:isoprenoid biosynthetic process
GO:0055114 P:oxidation reduction

References (5)

[1] “Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.”  Luskey K.L.et.al.   2991281
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.”  Istvan E.S.et.al.   10698924
[4] “Structural mechanism for statin inhibition of HMG-CoA reductase.”  Istvan E.S.et.al.   11349148
[5] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.”  Cargill M.et.al.   10391209
Structure:
1DQ8   1DQ9   1DQA   1HW8   1HW9   1HWI   1HWJ   1HWK   1HWL   2Q1L   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS 
61:	DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 
121:	LNEALPFFLL LIDLSRASTL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 
181:	VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR 
241:	VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTADTSKVS LGLDENVSKR 
301:	IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QTETESTLSL KNPITSPVVT 
361:	QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI KPLVAETDTP NRATFVVGNS 
421:	SLLDTSSVLV TQEPEIELPR EPRPNEECLQ ILGNAEKGAK FLSDAEIIQL VNAKHIPAYK 
481:	LETLMETHER GVSIRRQLLS KKLSEPSSLQ YLPYRDYNYS LVMGACCENV IGYMPIPVGV 
541:	AGPLCLDEKE FQVPMATTEG CLVASTNRGC RAIGLGGGAS SRVLADGMTR GPVVRLPRAC 
601:	DSAEVKAWLE TSEGFAVIKE AFDSTSRFAR LQKLHTSIAG RNLYIRFQSR SGDAMGMNMI 
661:	SKGTEKALSK LHEYFPEMQI LAVSGNYCTD KKPAAINWIE GRGKSVVCEA VIPAKVVREV 
721:	LKTTTEAMIE VNINKNLVGS AMAGSIGGYN AHAANIVTAI YIACGQDAAQ NVGSSNCITL 
781:	MEASGPTNED LYISCTMPSI EIGTVGGGTN LLPQQACLQM LGVQGACKDN PGENARQLAR 
841:	IVCGTVMAGE LSLMAALAAG HLVKSHMIHN RSKINLQDLQ GACTKKTA