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2.A.60.1.12
OAT8/1B3(SLC21A) The bile acid (cholic acid)/glutathione (GSH:bile acid = 2.1) exporter (Briz et al., 2006). Also transports the octapeptide, cholecystokinin (CCK-8) (Gui and Hagenbuch, 2008) and danoprevir (hepatitis C virus protease inhibitor) (Brennan et al. 2015). Forms homo and hetero oligomers, but the monomer is the active species (Brennan et al. 2015). Forms homo and hetero oligomers, but the monomer is the active species (Zhang et al. 2017).

Accession Number:Q9NPD5
Protein Name: OATP8
Length:702
Molecular Weight:77403.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basal cell membrane1 / Multi-pass membrane protein2
Substrate Cholate, Glutathione, Cholecystokinin, Danoprevir

Cross database links:

NOG322696HOG000231269
Genevestigator: Q9NPD5 Q9NPD5
RefSeq: NP_062818.1   
Entrez Gene ID: 28234   
Pfam: PF07648    PF03137   
OMIM: 605495  gene
KEGG: hsa:28234    hsa:28234   

Gene Ontology

GO:0009925 C:basal plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0016328 C:lateral plasma membrane
GO:0015125 F:bile acid transmembrane transporter activity
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015711 P:organic anion transport
GO:0016323 C:basolateral plasma membrane
GO:0005737 C:cytoplasm
GO:0008514 F:organic anion transmembrane transporter activity
GO:0015721 P:bile acid and bile salt transport
GO:0008206 P:bile acid metabolic process
GO:0043252 P:sodium-independent organic anion transport

References (7)

[1] “Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.”  Koenig J.et.al.   10779507
[2] “LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.”  Abe T.et.al.   11375950
[3] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[4] “Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.”  Koenig J.et.al.   10779507
[5] “LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.”  Abe T.et.al.   11375950
[6] “Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.”  van de Steeg E.et.al.   22232210
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI SITQIERRFD 
61:	ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CLLMGTGSIL TSLPHFFMGY 
121:	YRYSKETHIN PSENSTSSLS TCLINQTLSF NGTSPEIVEK DCVKESGSHM WIYVFMGNML 
181:	RGIGETPIVP LGISYIDDFA KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV 
241:	DLSTIRITPK DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK 
301:	TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS SFIGSFTYVF 
361:	KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF KLSLVGIAKF SFLTSMISFL 
421:	FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS HVDVPLSYCN SECNCDESQW EPVCGNNGIT 
481:	YLSPCLAGCK SSSGIKKHTV FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI 
541:	QVINSLFSAT GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM 
601:	KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK FQGKDTKASD 
661:	NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA AN