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2.A.60.1.14
The Na+-independent organic anion transporter, OATP-A (OatP1, Oat1A2, OatP1A2, SLC21A3, SLCO1A2 of 670 aas).  Transports various anions such as cholate and taurocholate as well as the quinolone antibacterial agent levofloxacin and Ochratoxin (Ota) (Maeda et al., 2007; Qi et al. 2017). Also transports thyroid hormones. The transport of primary and secondary thyroid hormone transporters has been reviewed (Kinne et al., 2011).  Transports luciferin, the substrate of luciferase (Patrick et al. 2014).

Accession Number:P46721
Protein Name: OATP-A aka SLCO1A2
Length:670
Molecular Weight:74145.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cholate, taurocholate, Quinolones, Levofloxacin, Thyroid hormones, Luciferin

Cross database links:

Genevestigator: P46721 P46721
eggNOG: prNOG08535 NOG256971
HEGENOM: HBG717600 HOG000231269
RefSeq: NP_066580.1    NP_602307.1   
Entrez Gene ID: 6579   
Pfam: PF07648    PF03137   
OMIM: 602883  gene
KEGG: hsa:6579    hsa:6579   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015125 F:bile acid transmembrane transporter activity
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015711 P:organic anion transport
GO:0008514 F:organic anion transmembrane transporter activity
GO:0015721 P:bile acid and bile salt transport
GO:0008206 P:bile acid metabolic process
GO:0043252 P:sodium-independent organic anion transport

References (11)

[1] “Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.”  Kullak-Ublick G.-A.et.al.   7557095
[2] “Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.”  Koenig J.et.al.   10779507
[3] “Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.”  Speek M.et.al.   11238933
[4] “Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.”  Lee W.et.al.   15632119
[5] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[6] “Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.”  Kullak-Ublick G.-A.et.al.   7557095
[7] “Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.”  Koenig J.et.al.   10779507
[8] “Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.”  Speek M.et.al.   11238933
[9] “Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.”  Bailey D.G.et.al.   17301733
[10] “Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.”  Lee W.et.al.   15632119
[11] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ FNIPTSLVGF 
61:	INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC FLKSLPHFLM NQYEYESTVS 
121:	VSGNLSSNSF LCMENGTQIL RPTQDPSECT KEVKSLMWVY VLVGNIVRGM GETPILPLGI 
181:	SYIEDFAKFE NSPLYIGLVE TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR 
241:	WVGAWWFGFL ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG 
301:	ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS SSDAIFLMGI 
361:	YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL LYFLSFLMTC ENSSVVGINT 
421:	SYEGIPQDLY VENDIFADCN VDCNCPSKIW DPVCGNNGLS YLSACLAGCE TSIGTGINMV 
481:	FQNCSCIQTS GNSSAVLGLC DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK 
541:	SEEKSLGVGL HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI 
601:	YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE CKDIYQKSTV 
661:	LKDDELKTKL