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2.A.60.1.15
OAT family 1C1 protein, isoform 1, Oatp1c1; transports thyroid horomone and other organic anions (Westholm et al. 2010). (83% identical to 2.A.60.1.10). Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011) and (Bernal et al. 2015). Together with MTC8 (TC# 2.A.1.13.10), OATP1C1 controls skeletal muscle regeneration (Mayerl et al. 2018).

Accession Number:Q9NYB5
Protein Name:Solute carrier organic anion transporter family member 1C1
Length:712
Molecular Weight:78696.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Thyroid hormones, Organoanions

Cross database links:

NOG305397HOG000231269
Genevestigator: Q9NYB5 Q9NYB5
Entrez Gene ID: 53919   
Pfam: PF07648    PF03137   
KEGG: hsa:53919    hsa:53919   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0043252 P:sodium-independent organic anion transport
GO:0005886 C:plasma membrane
GO:0015125 F:bile acid transmembrane transporter activity
GO:0055085 P:transmembrane transport

References (7)

[1] “Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.”  Pizzagalli F.et.al.   12351693
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.”  Pizzagalli F.et.al.   12351693
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.”  Roberts L.M.et.al.   18687783

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDTSSKENIQ LFCKTSVQPV GRPSFKTEYP SSEEKQPCCG ELKVFLCALS FVYFAKALAE 
61:	GYLKSTITQI ERRFDIPSSL VGVIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCVIMG 
121:	VGTLLIAMPQ FFMEQYKYER YSPSSNSTLS ISPCLLESSS QLPVSVMEKS KSKISNECEV 
181:	DTSSSMWIYV FLGNLLRGIG ETPIQPLGIA YLDDFASEDN AAFYIGCVQT VAIIGPIFGF 
241:	LLGSLCAKLY VDIGFVNLDH ITITPKDPQW VGAWWLGYLI AGIISLLAAV PFWYLPKSLP 
301:	RSQSREDSNS SSEKSKFIID DHTDYQTPQG ENAKIMEMAR DFLPSLKNLF GNPVYFLYLC 
361:	TSTVQFNSLF GMVTYKPKYI EQQYGQSSSR ANFVIGLINI PAVALGIFSG GIVMKKFRIS 
421:	VCGAAKLYLG SSVFGYLLFL SLFALGCENS DVAGLTVSYQ GTKPVSYHER ALFSDCNSRC 
481:	KCSETKWEPM CGENGITYVS ACLAGCQTSN RSGKNIIFYN CTCVGIAASK SGNSSGIVGR 
541:	CQKDNGCPQM FLYFLVISVI TSYTLSLGGI PGYILLLRCI KPQLKSFALG IYTLAIRVLA 
601:	GIPAPVYFGV LIDTSCLKWG FKRCGSRGSC RLYDSNVFRH IYLGLTVILG TVSILLSIAV 
661:	LFILKKNYVS KHRSFITKRE RTMVSTRFQK ENYTTSDHLL QPNYWPGKET QL