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2.A.60.1.19
Solute carrier organic anion transporter family member 2A1 (Prostaglandin uptake transporter, PGT) (Solute carrier family 21 member 2). Transports prostaglandin E2 and plays a role in F4 mediated neonatal diarrhoea. (Schuster 2002; Ohkura et al. 2014).

Accession Number:Q92959
Protein Name:Solute carrier organic anion transporter family member 2A1
Length:643
Molecular Weight:70044.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Organoanions, Prostaglandin E2

Cross database links:

Genevestigator: Q92959
eggNOG: NOG271773
HEGENOM: HOG000231269
Entrez Gene ID: 6578   
Pfam: PF07648    PF03137   
KEGG: hsa:6578   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005319 F:lipid transporter activity
GO:0015132 F:prostaglandin transmembrane transporter activity
GO:0043252 P:sodium-independent organic anion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT).”  Lu R.et.al.   8787677
[2] “Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization.”  Lu R.et.al.   9618293
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy.”  Zhang Z.et.al.   22197487
Structure:
3MRR     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA YFKSSLTTIE 
61:	KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL IGIGGLFLAA GAFILTLPHF 
121:	LSEPYQYTLA STGNNSRLQA ELCQKHWQDL PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA 
181:	GIGTVPIQPF GISYVDDFSE PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN 
241:	TAAVNLVPGD PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE 
301:	EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN KFLEKQYGTS 
361:	AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI ATTIITISMI LCVPLFFMGC 
421:	STPTVAEVYP PSTSSSIHPQ SPACRRDCSC PDSIFHPVCG DNGIEYLSPC HAGCSNINMS 
481:	SATSKQLIYL NCSCVTGGSA SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV 
541:	LRVVNQEEKS FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND 
601:	ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI