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2.A.61.1.1
Anaerobic C4-dicarboxylate transporter (DcuC) which functions to transport dicarboxylates during glucose fermentation (Zientz et al. 1999).  Also facilitates succinate efflux (Chen et al. 2014).

Accession Number:P0ABP3
Protein Name:Anaerobic C4-dicarboxylate transporter DcuC aka B0621
Length:461
Molecular Weight:48412.00
Species:Escherichia coli [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate C4-dicarboxylates

Cross database links:

Genevestigator: P0ABP3
EchoBASE: EB3315
EcoGene: EG13545
eggNOG: COG3069
HEGENOM: HBG625535
RefSeq: AP_001268.1    AP_001270.1    NP_415154.1   
Entrez Gene ID: 945000   
Pfam: PF03606   
BioCyc: EcoCyc:DCUC-MONOMER    ECOL168927:B0621-MONOMER   
KEGG: eco:b0621   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015556 F:C4-dicarboxylate transmembrane transporter ...
GO:0015740 P:C4-dicarboxylate transport

References (6)

[1] “Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange.”  Zientz E.et.al.   8955408
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli.”  Zientz E.et.al.   10368146
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL PSSQASTGYS 
61:	ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND MVVKLASKPL QYINSPYLLM 
121:	IAAYFVACLM SLAVSSATGL GVLLMATLFP VMVNVGISRG AAAAICASPA AIILAPTSGD 
181:	VVLAAQASEM SLIDFAFKTT LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT 
241:	TAPAFYAILP FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE 
301:	VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL MLVLVILTML 
361:	AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA SNLGRTLSPV SGVVVAVAGM 
421:	AKISPFEVVK RTSVPVLVGL VIVIVATELM VPGTAAAVTG K