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2.A.65.1.1
The bilirubin transporter (bilitranslocase; BLT) of 340 aas and 3 or 4 TMSs. A structural model has been proposed (Roy Choudhury et al. 2015).  Strangely, no homologues are present in the NCBI protein database as of September, 2019, even from another mammal. A possible distant homologue is a hypothetical protein AUH14_01145 of 333 aas and 1 - 3 TMSs, the Candidatus Rokubacteria bacterium 13_2_20CM_69_15_1] (ACCESSION # OLB08456).  Structural analyses of TMSs in different micellar environments have been published (Szutkowski et al. 2019).

Accession Number:O88750
Protein Name:Bilitranslocase
Length:340
Molecular Weight:38216.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass membrane protein2
Substrate bilirubin

Cross database links:

Genevestigator: O88750

Gene Ontology

GO:0046658 C:anchored to plasma membrane
GO:0005615 C:extracellular space
GO:0005507 F:copper ion binding
GO:0004322 F:ferroxidase activity
GO:0007568 P:aging
GO:0006879 P:cellular iron ion homeostasis
GO:0001889 P:liver development
GO:0030324 P:lung development
GO:0015679 P:plasma membrane copper ion transport
GO:0046688 P:response to copper ion
GO:0007584 P:response to nutrient

References (1)

[1] “The bilirubin-binding motif of bilitranslocase and its relation to conserved motifs in ancient biliproteins.”  Battiston L.et.al.   9647754

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLIHNWILTF SIFREHPSTV FQIFTKCILV SSSFLLFYTL LPHGLLEDLM RRVGDSLVDL 
61:	IVICEDSQGQ HLSSFCLFVA TLQSPFSAGV SGLCKAILLP SKQIHVMIQS VDLSIGITNS 
121:	LTNEQLCGFG FFLNVKTNLH CSRIPLITNL FLSARHMSLD LENSVGSYHP RMIWSVTWQW 
181:	SNQVPAFGET SLGFGMFQEK GQRHQNYEFP CRCIGTCGRG SVQCAGLISL PIAIEFTYQL 
241:	TSSPTCIVRP WRFPNIFPLI ACILLLSMNS TLSLFSFSGG RSGYVLMLSS KYQDSFTSKT 
301:	RNKRENSIFF LGLNTFTDFR HTINGPISPL MRSLTRSTVE