| TCID | Name | Organismal Type | Example |
|---|---|---|---|
| 2.A.66.1: The Multi Antimicrobial Extrusion (MATE) Family | |||
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2.A.66.1.1 | Drug:Na antiporter (norfloxacin, ethidium, kanamycin, ciprofloxin, streptomycin efflux pump), NorM. | Bacteria | NorM of Vibrio parahaemolyticus (O82855) |
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2.A.66.1.2 | Drug:Na+ antiporter, VcmA (exports norfloxacin, ciprofloxacin, ofloxacin, daunomycin, doxorubicin, streptomycin, kanamycin, ethidium, 4',6'-diamidino-2-phenylindole, hoechst33342 and acriflavin). The 3-d x-ray structure (3.65Å resolution) is available (He et al., 2010). Ion binding and internal hydration have been studied by molecular dynamics simulations (Vanni et al., 2012). | Bacteria | VcmA (NorM) of Vibrio cholerae non-01 |
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2.A.66.1.3 | Multidrug-resistance efflux pump, NorM (MdtK, NorE or YdhE) (exports chloramphenicol, norfloxacin, enoxacin, phosphomycin, doxorubicin, trimethoprim, ethidium, deoxycholate, etc.) (Long et al., 2008). May also export signals for cell-cell communication (Yang et al., 2006). | Bacteria | NorM (YdhE) of E. coli |
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2.A.66.1.4 | Bacteria | DinF of E. coli | |
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2.A.66.1.5 | Yeast | ERC1 (YHR032w) of Saccharomyces cerevisiae | |
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2.A.66.1.6 | Plants | Alf5 of Arabidopsis thaliana | |
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2.A.66.1.7 | Bacteria | VmrA of Vibrio parahaemolyticus | |
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2.A.66.1.8 | Plants | AtDTX1 of Arabidopsis thaliana | |
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2.A.66.1.9 | Bacteria | NorM of Burkholderia vietnamiensis | |
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2.A.66.1.10 | Na -dependent cationic drug (ethidium, acriflavine, 2-N-methyl ellipticinium, berberine, norfloxacin, ciprofloxacin, rhodamine 6G, crystal violet, doxorubicin, novobiocin, enoxacin, and tetraphenylphosphonium chloride) efflux pump, NorM (Long et al. 2008). 3-d structures of the N. gonorrheae NorM transporter (96% identical to the N. miningitidis protein) have been solved complexed with three different substrates in a multidrug cavity and Cs (4HUN; Lu et al. 2013). | Bacteria | NorM of Neisseria meningitidis |
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2.A.66.1.11 | Plants | EDS5 of Arabidopsis thaliana chloroplasts | |
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2.A.66.1.12 |
Drug:H+ antiporter (benzalkonium chloride, fluoroquinolone, ethidium bromide, acriflavin, tetraphenylphosphonium chloride efflux pump), PmpM (He et al., 2004) | Bacteria | PmpM of Pseudomonas aeruginosa (Q9I3Y3) |
|
2.A.66.1.13 | Drug (monovalent and divalent biocides; fluoroquinolones including norfloxacin and ciprofloxacin) efflux pump, SvrA (MepA) (Kaatz et al., 2006). Also exports tigecycline (McAleese et al., 2005). | Bacteria | SvrA of Staphylococcus aureus (Q2G140) |
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2.A.66.1.14 | Human MATE1 electroneutral organocation:H antiporter (transports tetraethylammonium and cimetidine as well as cisplatin and oxaliplatin) (Yonezawa et al., 2006). MATE1 also exports chloroquine across the renal luminal membrane (Müller et al., 2011). It has an established 13 TMS topology with the "extra" TMS in an extracellular C-terminal region that is not essential for function (Zhang et al., 2012). | Animals | SLC47A1 of Homo sapiens |
|
2.A.66.1.15 |
Electroneutral Multidrug & Toxin Extrusion-1 organic cation:H+ antiporter (MATE-1). Exports tetraethylammonium (TEA) and cimetidine, and probably other organic cations, such as 1-methyl-4-phenylpyridinium, amiloride, imipramine, and quinidine (Ohta et al., 2006). | Animals | MATE-1 of Rattus norvegicus (Q5I0E9) |
|
2.A.66.1.16 |
Electroneutral organic cation:H+ antiporter MATE2 (Hiasa et al., 2007). 50% identical to MATE1; 2.A.66.1.15. | Mammals | MATE2 of Mus musculus (Q3V050) |
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2.A.66.1.17 | Ciliates | MatE of Tetrahymena thermophila | |
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2.A.66.1.18 |
MATE1b (mediates tetraethylammonium (TEA) uptake with properties similar to that of mMATE1; localized in renal brush border membranes (Kobara et al., 2008)). | Metazoa | MATE1b of Mus musculus (Q8K0H1) |
|
2.A.66.1.19 |
JAT1 (transports nicotine and anabasine, and other alkaloids, such as hyoscyamine and berberine, but not flavonoids) (Morita et al., 2009). | Plants | JAT1 of Nicotiana tabacum (B7ZGMO) |
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2.A.66.1.20 | Multidrug and Toxin Extrusion Protein 2, MATE-2 (catalyzes drug:H+ antiport; broad specificity, low affinity (50-3000 μM) for organic cationic and anionic compounds (Tanihara et al., 2007)). | Animals | SLC47A2 of Homo sapiens |
|
2.A.66.1.21 | H+-coupled multidrug efflux pump, AbeM (most like 2.A.66.1.2, NorM of Vibrio cholerae) (Su et al., 2005). Exports norfloxacin, ciprofloxacin, DAPI, acriflavin, Hoechst 33342, daunorubicin, doxorubicin, and ethidium (Su et al., 2005). | Bacteria | AbeM of Acinetobacter baumannii (Q5FAM9) |
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2.A.66.1.22 | Bacteria | EmmdR of Enterobacter cloacae (D5CJ69) | |
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2.A.66.1.23 | MDR efflux pump (81.8% identical to 2.A.66.1.22) transports dipeptides (see 2.A.1.2.55) (Hayashi et al., 2010). | Bacteria | YeeO of E. coli (P76352) |
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2.A.66.1.24 | FRD3 efflux pump for citrate; involved in iron homeostasis. Loads citrate into xylem tissues facilitating iron transport to shoots; null mutants are sterile (Roschzttardtz et al., 2011; Durrett et al., 2007). | Plants | FRD3 of Arabidopsis thaliana (Q9SFB0) |
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2.A.66.1.25 | Bacilli | YoeA of Bacillus subtilis | |
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2.A.66.1.26 | Archaea | MJ0709 of Methanocaldococcus jannaschii | |
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2.A.66.1.27 | Bacteria | NorM of Caulobacter crescentus | |
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2.A.66.1.28 | Bacteria | NorM of Thermotoga maritima | |
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2.A.66.1.29 | Proteobacteria | MATE exporter protein of Myxococcus xanthus | |
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2.A.66.1.30 | Proteobacteria | AbeM2 of Acinetobacter baumannii | |
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2.A.66.1.31 | Proteobacteria | AbeM4 of Acinetobacter baumannii | |
| 2.A.66.2: The Polysaccharide Transport (PST) Family | |||
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2.A.66.2.1 | Lipopolysaccharide (possibly the O-antigen side chain intermediate) exporter | Gram-negative bacteria | RfbX1 of E. coli |
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2.A.66.2.2 | Gram-negative bacteria | ExoT of Rhizobium meliloti | |
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2.A.66.2.3 | Gram-negative bacteria | WzxE of E. coli (P0AAA7) | |
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2.A.66.2.4 | Gram-negative bacteria | AceE of Acetobacter xylinus | |
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2.A.66.2.5 | Gram-positive bacteria | CapF of Staphylococcus aureus | |
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2.A.66.2.6 | Gram-positive bacteria | TuaB of Bacillus subtilis | |
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2.A.66.2.7 | Gram-negative bacteria | WzxC of E. coli | |
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2.A.66.2.8 | Gram-negative bacteria | AmsL of Erwinia amylovora | |
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2.A.66.2.9 | Archaea | Mth342 of Methanobacterium thermoautotrophicum (O26442) | |
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2.A.66.2.10 | Archaea | Mth347 of Methanobacterium thermoautotrophicum(O26447) | |
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2.A.66.2.11 |
Exopolysaccharide exporter, EpsE (Huang and Schell, 1995) | Bacteria | EpsE of Ralstonia solanacearum (Q45411) |
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2.A.66.2.12 | Isoprenoid lipid sugar glycan flippase, Wzx (note: Wzx forms a complex with Wzy and Wzz for assembly of periplasmic O-antigen) (Marolda et al., 2006). Wzx has a 12 TMS topology (Cunneen and Reeves, 2008). WzyE (450aas; 12 TMSs; TC#9.B.128.1.1; B614D1) is called the enterobacterial common antigen (ECA) polysaccharide chain elongation polymerase (Marolda et al., 2006). | Bacteria | Wzx of E. coli (Q1L811) |
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2.A.66.2.13 | Bacteria | Unknown PST protein of Alteromonadales bacterium (A0XZ57) | |
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2.A.66.2.14 | The 14 TMS SpoVB protein (possibly catalyzes lipid-linked oligosaccharide transport across the cytoplasmic membrane; required for proper cell wall biosynthesis) (Vasudevan et al., 2009). | Firmicutes | The SpoVB protein of Bacillus subtilis (Q00758) |
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2.A.66.2.15 | Anionic O-antigen (undecaprenyl pyrophosphate-linked anionic O-Ag) subunit flippase, Wzx. Translocates from the inner to the outer leaflets of the inner membrane. The topology has been studied (Ormazabal et al. 2010). | Bacteria | Wzx of Pseudomonas aeruginosa (G3XD19) |
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2.A.66.2.16 | Bacteria | CpsS of Streptococcus thermophilus (Q8KUK6) | |
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2.A.66.2.17 | Bacilli | ||
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2.A.66.2.18 | O-antigen transmembrane translocase, Wzx (Franklin et al. 2011). In S. enterica groups B, D2 and E, Wzx translocation exhibits specificity for the repeat-unit structure, as variants with single sugar differences are translocated with lower efficiency, and little long-chain O antigen is produced. It appears that Wzx translocases are specific for their O antigen for normal levels of translocation (Hong et al. 2012). | Bacteria | Wzx of Salmonella enterica subsp. enterica |
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2.A.66.2.19 | O-antigen transmembrane translocase, Wzx (Franklin et al. 2011). For S. enterica groups B, D2 and E, Wzx translocation exhibits specificity for the repeat-unit structure, as variants with single sugar differences are translocated with lower efficiency, and little long-chain O antigen is produced. It appears that Wzx translocases are specific for their O antigen for normal levels of translocation (Hong et al. 2012). | Bacteria | Wzx of Salmonella typhimurium subsp. houtenae |
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2.A.66.2.20 | Chlamydiae | Hypothetical protein of Parachlamydia acanthamoebae | |
| 2.A.66.3: The Oligosaccharidyl-lipid Flippase (OLF) Family | |||
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2.A.66.3.1 | The OLF (Rft1 protein) of Saccharomyces cerevisiae | Eukaryotes | Rft1 of Saccharomyces cerevisiae |
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2.A.66.3.2 | Animals | RFT1 homologue of Homo sapiens (Q96AA3) | |
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2.A.66.3.3 | Plants | RFT1 homologue of Arabidopsis arenosa (Q6V5B3) | |
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2.A.66.3.4 | Ciliates | RFT1 homologue of Paramecium tetraurelia (A0D5K0) | |
| 2.A.66.4: The Mouse Virulence Factor (MVF) Family | |||
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2.A.66.4.1 | The mouse virulence factor, MviN. (May flip the Lipid II peptidoglycan precursor from the cytoplasmic side of the inner membrane to the periplasmic surface) (Vasudevan et al., 2009). MviN, a putative lipid flippase (Fay and Dworkin, 2009). In E. coli, MviN is an essential protein which when defective results in the accumulation of polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine. This may be the peptidoglycan intermediated exported via MviN (Inoue et al. 2008). It is essential for the growth of several bacteria. | Bacteria | MviN of Salmonella typhimurium (P37169) |
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2.A.66.4.2 | Bacteria | MviN of Borrelia garinii (Q65ZW3) | |
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2.A.66.4.3 | Bacteria | MurJ of Escherichia coli | |
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2.A.66.4.4 | MviN. Essential for peptidoglycan biosynthesis (Gee et al. 2012). | Actinobacteria | MviN of Mycobacterium tuberculosis |
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2.A.66.4.5 | MviN; LuxO regulated for induction during the early logarithmic and stationary phase of growth (Cao et al. 2010). | Enterobacteria | MviN of Vibrio alginolyticus |
| 2.A.66.5: The Agrocin 84 Antibiotic Exporter (AgnG) Family | |||
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2.A.66.5.1 | The agrocin 84 exporter, AgnG | Bacteria | AgnG of Agrobacterium tumefaciens (Q676G9) |
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2.A.66.5.2 | Bacteria | AgnG homologue 1 of Nitrococcus mobilis (A4BUA1) | |
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2.A.66.5.3 | Bacteria | AgnG homologue 2 of Lyngbya sp. PCC8106 (A0YL48) | |
| 2.A.66.6: The Putative Exopolysaccharide Exporter (EPS-E) Family | |||
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2.A.66.6.1 | Putative exopolysaccharide transporter, PelG (456 aas, 12TMSs) (COG4267) (Vasseur et al., 2007) | Bacteria | PelG of Pseudomonas aeruginosa (Q02PM3) |
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2.A.66.6.2 | Bacteria | Fusion protein of Ralstonia solanacearum (EAP70965) | |
| 2.A.66.7: Putative O-Unit Flippase (OUF) Family | |||
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2.A.66.7.1 | Putative O-unit flippase (OUF1) | Bacteria | OUF1 of Pseudomonas fluorescens (Q4K6F5) |
| 2.A.66.8: Unknown MOP-1 (U-MOP1) Family (Most closely related to the OLF Family (2.A.66.3)) | |||
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2.A.66.8.1 | Hypothetical protein (598aas; 12-14TMSs) | Protozoa | Hypothetical protein of Trypanosoma brucei (Q383B3) |
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2.A.66.8.2 | Protozoa | Hypothetical protein of Leishmania infantum (A4I3X2) | |
| 2.A.66.9: The Progressive Ankylosis (Ank) Family | |||
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2.A.66.9.1 | The progressive ankylosis (ANK) protein homologue (AnkH) gives rise to craniometaphyseal bone dysplasia in man. It has 12 putative TMSs (Nürnberg et al., 2001) | Animals | AnkH of Homo sapiens (Q9HCJ1) |
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2.A.66.9.2 | Bacteria | Pcar_0400 of Pelobacter carbinolicus (Q3A7I4) | |
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2.A.66.9.3 | Bacteria | Ank protein of Desulfuromonas acetoxidans (Q1K211) | |
| 2.A.66.10: LPS Precursor Flippase (LPS-F) Family | |||
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2.A.66.10.1 | Wzx isoprenoid-linked O-antigen precursor glycan translocase. A 12 TMS topology with N- and C-termini in the cytoplasm has been estabilshed, and functionally important residues have been identified (Marolda et al. 2010). | Proteobacteria |
Wzx of E. coli O157:H7 str 1125 |
| 2.A.66.11: Uncharacterized MOP-11 (U-MOP11) Family | |||
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2.A.66.11.1 | Uncharacterized protein | Actinobacteria | Uncharacterized protein of Streptomyces coelicolor |
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2.A.66.11.2 | Proteobacteria | Uncharacterized protein of Beggiatoa alba | |
| 2.A.66.12: Uncharacterized MOP-12 (U-MOP12) Family | |||
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2.A.66.12.1 | Uncharacterized MOP superfamily member of 506 aas and 14 TMSs | δ-Proteobacteria | U-MOP family 12 member-1 |
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2.A.66.12.2 | Bacteroidetes | U-MOP family 12 member-2 | |
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2.A.66.12.3 | Archaea | U-MOP family 12 member-3 | |
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2.A.66.12.4 | Archaea | U-MOP superfamily protein | |
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2.A.66.12.5 | Archaea | U-MOP superfamily member | |
