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2.A.66.1.4
DNA damage-inducible protein F, DinF.  Protects against oxidative stress and bile salts, possibly by pumping relevant compounds out of the cytoplasm (Rodríguez-Beltrán et al. 2012).

Accession Number:P28303
Protein Name:DinF aka B4044
Length:459
Molecular Weight:49646.00
Species:Escherichia coli [83333]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate bile salts, Unknown

Cross database links:

Genevestigator: P28303
EchoBASE: EB1454
EcoGene: EG11491
eggNOG: COG0534
HEGENOM: HBG675854
RefSeq: AP_004545.1    NP_418468.3   
Entrez Gene ID: 948554   
Pfam: PF01554   
BioCyc: EcoCyc:DINF-MONOMER    ECOL168927:B4044-MONOMER   
KEGG: ecj:JW4004    eco:b4044   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (4)

[1] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPPGVAVCFS SLFIRLVCMA FLTSSDKALW HLALPMIFSN ITVPLLGLVD TAVIGHLDSP 
61:	VYLGGVAVGA TATSFLFMLL LFLRMSTTGL TAQAYGAKNP QALARTLVQP LLLALGAGAL 
121:	IALLRTPIID LALHIVGGSE AVLEQARRFL EIRWLSAPAS LANLVLLGWL LGVQYARAPV 
181:	ILLVVGNILN IVLDVWLVMG LHMNVQGAAL ATVIAEYATL LIGLLMVRKI LKLRGISGEM 
241:	LKTAWRGNFR RLLALNRDIM LRSLLLQLCF GAITVLGARL GSDIIAVNAV LMTLLTFTAY 
301:	ALDGFAYAVE AHSGQAYGAR DGSQLLDVWR AACRQSGIVA LLFSVVYLLA GEHIIALLTS 
361:	LTQIQQLADR YLIWQVILPV VGVWCYLLDG MFIGATRATE MRNSMAVAAA GFALTLLTLP 
421:	WLGNHALWLA LTVFLALRGL SLAAIWRRHW RNGTWFAAT