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2.A.66.1.8
Plasma membrane efflux pump, AtDTX1, for plant alkaloids, drugs (e.g., norfloxacin), antibiotics and Cd2+ (Li et al. 2002). 

Accession Number:Q9SIA5
Protein Name:AtDTX1 aka AT2G04040
Length:476
Molecular Weight:51845.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Early endosome membrane1 / Multi-pass membrane protein2
Substrate norfloxacin, antibiotics, Plant alkaloids, Cd2+

Cross database links:

Genevestigator: Q9SIA5
eggNOG: KOG1347
HEGENOM: HBG746942
RefSeq: NP_178491.1   
Entrez Gene ID: 814938   
Pfam: PF01554   
KEGG: ath:AT2G04040   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015559 ?:?
GO:0015691 P:cadmium ion transport
GO:0006855 P:drug transmembrane transport
GO:0051238 P:sequestering of metal ion

References (1)

[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEPFLLRDE LLVPSQVTWH TNPLTVELKR VSRLAAPMAT VTIAQYLLPV ISVMVAGHNG 
61:	ELQLSGVALA NSFTNVTGFS IMCGLVGALE TLCGQAYGAK QYEKIGTYAY SAIASNIPIC 
121:	FLISILWLYI EKILISLGQD PEISRIAGSY AFWLIPALFG QAIVIPLSRF LLTQGLVIPL 
181:	LFTAVTTLLF HVLVCWTLVF LFGLGCNGPA MATSVSFWFY AVILSCYVRF SSSCEKTRGF 
241:	VSRDFVSSIK QFFQYGIPSA AMICLEWWLF EILILCSGLL PNPKLETSVL SICLTIETLH 
301:	YVISAGVAAA VSTRVSNNLG AGNPQVARVS VLAGLCLWIV ESAFFSILLF TCRNIIGYAF 
361:	SNSKEVLDYV ADLTPLLCLS FILDGFTAVL NGVARGSGWQ HIGAWNNTVS YYLVGAPVGI 
421:	YLAFSRELNG KGLWCGVVVG STVQATILAI VTASINWKEQ AEKARKRIVS TENRLA