TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.66.4.1
The mouse virulence factor, MviN. (May flip the Lipid II peptidoglycan precursor from the cytoplasmic side of the inner membrane to the periplasmic surface) (Vasudevan et al., 2009). MviN, a putative lipid flippase (Fay and Dworkin, 2009).  In E. coli, MviN is an essential protein which when defective results in the accumulation of polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine.  This may be the peptidoglycan intermediated exported via MviN (Inoue et al. 2008).  It is essential for the growth of several bacteria.

Accession Number:P37169
Protein Name:MviN aka STM1170
Length:524
Molecular Weight:57315.00
Species:Salmonella typhimurium [90371]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Lipid II peptidoglycan precursors

Cross database links:

HEGENOM: HBG731814
RefSeq: NP_460141.1   
Entrez Gene ID: 1252688   
Pfam: PF03023   
BioCyc: STYP99287:STM1170-MONOMER   
KEGG: stm:STM1170   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009405 P:pathogenesis

References (2)

[1] “Sequence analysis of the flgA gene and its adjacent region in Salmonella typhimurium, and identification of another flagellar gene, flgN.”  Kutsukake K.et.al.   8200538
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQEFYARVWN TKEMNLLKSL AAVSSMTMFS RVLGFARDAI VARIFGAGMA TDAFFVAFKL 
61:	PNLLRRIFAE GAFSQAFVPI LAEYKSKQGE EATRIFVAYV SGLLTLALAV VTVAGMLAAP 
121:	WVIMVTAPGF ADTADKFALT TQLLRITFPY ILLISLASLV GAILNTWNRF SIPAFAPTFL 
181:	NISMIGFALF AAPYFNPPVL ALAWAVTVGG VLQLVYQLPY LKKIGMLVLP RINFRDTGAM 
241:	RVVKQMGPAI LGVSVSQISL IINTIFASFL ASGSVSWMYY ADRLMEFPSG VLGVALGTIL 
301:	LPSLSKSFAS GNHDEYCRLM DWGLRLCFLL ALPSAVALGI LAKPLTVSLF QYGKFTAFDA 
361:	AMTQRALIAY SVGLIGLIVV KVLAPGFYSR QDIKTPVKIA IVTLIMTQLM NLAFIGPLKH 
421:	AGLSLSIGLA ACLNASLLYW QLRKQNIFTP QPGWMWFLMR LIISVLVMAA VLFGVLHIMP 
481:	EWSQGSMLWR LLRLMAVVIA GIAAYFAALA VLGFKVKEFV RRTA