TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.68.1.2
The drug resistance permease, MtrF (Folster and Shafer, 2005).  The 3-d structure is known (Su et al. 2015). MtrF is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer (Su et al. 2015). Each subunit of the transporter contains nine transmembrane helices and two hairpins, posing a plausible pathway for substrate transport. A combination of the crystal structure and biochemical functional assays suggests that MtrF is an antibiotic efflux pump mediating bacterial resistance to sulfonamide antimetabolite drugs (Su et al. 2015). MtrF and YdaH, (TC#2.A.68.1.4) and the dicarboxylate transporter, INDY (TC#2.a.47.5.2) have been shown to have the same 3-d fold (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003).

Accession Number:Q5F721
Protein Name:Antibiotic resistance efflux pump component
Length:522
Molecular Weight:56178.00
Species:Neisseria gonorrhoeae (strain ATCC 700825/FA 1090) [242231]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: COG2978
HEGENOM: HBG683698
RefSeq: YP_208428.1   
Entrez Gene ID: 3281186   
Pfam: PF03806   
BioCyc: NGON242231:NGO1368-MONOMER   
KEGG: ngo:NGO1368   

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSQTDARRSG RFLRTVEWLG NMLPHPVTLF IIFIVLLLIA SAVGAYFGLS VPDPRPVGAK 
61:	GRADDGLIHV VSLLDADGLI KILTHTVKNF TGFAPLGTVL VSLLGVGIAE KSGLISALMR 
121:	LLLTKSPRKL TTFMVVFTGI LSNTASELGY VVLIPLSAVI FHSLGRHPLA GLAAAFAGVS 
181:	GGYSANLFLG TIDPLLAGIT QQAAQIIHPD YVVGPEANWF FMAASTFVIA LIGYFVTEKI 
241:	VEPQLGPYQS DLSQEEKDIR HSNEITPLEY KGLIWAGVVF VALSALLAWS IVPADGILRH 
301:	PETGLVAGSP FLKSIVVFIF LLFALPGIVY GRITRSLRGE REVVNAMAES MSTLGLYLVI 
361:	IFFAAQFVAF FNWTNIGQYI AVKGAVFLKE VGLGGSVLFI GFILICAFIN LMIGSASAQW 
421:	AVTAPIFVPM LMLAGYAPEV IQAAYRIGDS VTNIITPMMS YFGLIMATVI KYKKDAGVGT 
481:	LISMMLPYSA FFLIAWIALF CIWVFVLGLP VGPGTPTFYP VP