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TCID	Name	Organismal Type	Example
2.A.7.1: The 4 TMS Small Multidrug Resistance (SMR) Family
2.A.7.1.1	Small multidrug efflux pump (substrates: (1) aromatic dyes (e.g., ethidium bromide), (2) quarternary amines (e.g., the disinfectant benzalkonium) and (3) derivatives of tetraphenylphosphonium (TPP))	Bacteria	Smr of Staphylococcus aureus
2.A.7.1.2	Small multidrug efflux pump (substrates: tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y)	Bacteria	Mmr of Mycobacterium tuberculosis (P69926)
2.A.7.1.3	Small multidrug efflux pump (substrates: cationic lipophilic drugs). The 3-D structure of the dimeric EmrE shows opposite orientation of the two subunits in the membrane (Chen et al., 2007). There may be a single intermediate state in which the substrate is occluded and immobile (Basting et al., 2008). A Gly₉₀X₆Gly₉₇ motif is important for dimer formation (Elbaz et al., 2008).	Bacteria	EmrE of E. coli
2.A.7.1.4	Quaternary ammonium compound (cetylpyridinium, cetyldimethyl ethylammonium, hexadecyltrimethyl ammonium) efflux pump	Bacteria	SugE of E. coli (P69937)
2.A.7.1.5	The heterooligomeric drug resistance efflux pump, YkkCD (substrates: ethidium bromide, proflavin, tetraphenylarsonium chloride, crystal violet, pyronin Y, methylviologen, cetylperdinium chloride, streptomycin, tetracycline, chloramphenicol, phosphonomycin)	Bacteria	YkkCD of Bacillus subtilis
2.A.7.1.6	The heterooligomeric drug resistance efflux pump, EbrAB (substrates: ethidium bromide, acriflavin, pyronin Y, and safranin O) (Zhang et al., 2007).	Bacteria	EbrAB of Bacillus subtilis
2.A.7.1.7	The drug resistance efflux pump, Hsmr (Ninio and Schuldiner, 2003) (exports ethidium, acriflavin tetraphenylphosphonium (TPP) and other cationic drugs)	Archaea	Hsmr of Halobacterium salinarum (B0R6K7)
2.A.7.1.8	The putative heterodimeric SMR efflux pump, NepAB, encoded in a nicotine degradation plasmid, pAO1 (Baitsch et al., 2001; Brandsch, 2006); [probably exports methylamine; may also export excess nicotine, methylamine and/or the intermediate of nicotine catabolism, N-methyl-aminobutyrate] (Ganas et al. 2007). Uptake (Km=6μM) occurs by facilitated diffusion (Ganas and Brandsch, 2009).	Bacteria	NepAB of Arthrobacter nicotinovorans: NepA (116 aas; Q8GAI5) NepB (166 aas; Q8GAI6)
2.A.7.1.9	The spermidine exporter, MdtJI (Higashi et al., 2008)	Bacteria	MdtJI of E. coli MdtJ (P69213) MdtI (P69210)
2.A.7.2: The 5 TMS Bacterial/Archaeal Transporter (BAT) Family
2.A.7.2.1	Hypothethical protein	Bacteria	Ycb6 of Pseudomonas denitrificans
2.A.7.2.2	Hypothethical protein	Archaea	Orf of Pyrococcus abyssi
2.A.7.3: The 10 TMS Drug/Metabolite Exporter (DME) Family
2.A.7.3.1	Putative acetate efflux pump, MadN	Bacteria	MadN of Malonomonas rubra
2.A.7.3.2	YdeD efflux pump for O-acetylserine, cysteine, asparagine and glutamine (T. Dassler, Ph.D. thesis, Univ. Munich, Germany)	Bacteria	YdeD of E. coli
2.A.7.3.3	PecM Probable blue pigment (indigoidine) exporter	Bacteria	PecM of Erwinia chrysanthemi
2.A.7.3.4	YwfM	Bacteria	YwfM of Bacillus subtilis
2.A.7.3.5	Yf33	Archaea	Yf33 of Archaeoglobus fulgidus
2.A.7.3.6	RhtA (YbiF) Thronine/Homoserine Exporter (may export other amino acids including proline, serine, cysteine, histidine and several amino acid analogues, based on resistance phenotypes (Livshits et al., 2003))	Bacteria	RhtA (YbiF) of Escherichia coli (P0AA67)
2.A.7.3.7	The S-adenosylmethionine uptake transporter, Sam (Tucker et al., 2003) (may function by an exchange mechanism (i.e., S-adenosyl- methionine/S-adenosylhomocysteine exchange))	Bacteria	Sam (RPO76) of Rickettsia prowazekii
2.A.7.4: The Plant Drug/Metabolite Exporter (P-DME) Family
2.A.7.4.1	MtN21 nodulin protein	Plants	MtN21 of Medicago truncatula
2.A.7.4.2	Nodulin MfN21	Plant	MfN21 of Arabidopsis thaliana (NP_173898)
2.A.7.5: The Glucose/Ribose Porter (GRP) Family
2.A.7.5.1	Glucose uptake permease, GlcU	Gram-positive bacteria	GlcU (GltT) of Staphylococcus xylosus
2.A.7.5.2	Probable ribose transporter, RbsU	Gram-positive bacteria	RbsU of Lactobacillus sakei
2.A.7.5.3	Glucose:H⁺ symporter, GlcU (YxfA) (high specificity, low affinity) (Castro et al., 2009)	Low G+C, Gram-positive Bacteria	GlcU of Lactococcus lactis (Q9CDF7)
2.A.7.6: The L-Rhamnose Transporter (RhaT) Family
2.A.7.6.1	Rhamnose:H⁺ symporter, RhaT	Gram-negative bacteria	RhaT of E. coli
2.A.7.7: The Chloramphenicol-Sensitivity Protein (RarD) Family
2.A.7.7.1	The chloramphenicol-sensitive protein, RarD	Gram-negative bacteria	RarD of Pseudomonas aeruginosa
*2.A.7.8: The Caenorhabditis elegans* ORF (CEO) Family**
2.A.7.8.1	Hypothetical protein, Yrr6	Animals	Yrr6 of Caenorhabditis elegans
2.A.7.9: The Triose-phosphate Transporter (TPT) Family
2.A.7.9.1	Chloroplast triose-P/glycerate-3-P:P_i antiporter (TPT) (phosphoenolpyruvate and 2-phosphoglycerate are poor substrates).	Plants	TPT of Zea mays
2.A.7.9.2	Nongreen plastid/chloroplast glucose-P/triose-P/glycerate-P:P_i antiporter (GPT) (Both glucose-6-P and glucose-1-P are substrates; other hexose-Ps may also be transported). (Exchanges phosphoenolpyruvate for inorganic phosphate (Nozawa et al., 2007)	Plants	GPT of Brassica oleracea
2.A.7.9.3	Chloroplast phosphoenolpyruvate:P_i antiporter (PPT) (triose-Ps and glycerate- Ps are poor substrates).	Plants	PPT of Zea mays
2.A.7.9.4	Sly41p (transport function unknown)	Yeast	Sly41p of Saccharomyces cerevisiae
2.A.7.9.5	The plastidic phosphate/triosephosphate transporter, TPT (Linka et al., 2008).	Red algae	TPT Galdieria sulphuraria (B5AJT1)
2.A.7.10: The UDP-N-Acetylglucosamine:UMP Antiporter (UAA) Family
2.A.7.10.1	UDP-N-acetylglucosamine:UMP antiporter	Yeast, animals	Mnn2-2 of Kluyveromyces lactis
2.A.7.10.2	The bifunctional golgi nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine, SLC35B4 (Ashikov et al., 2005).	Animals	SLC35B4 of Homo sapiens (Q969S0)
2.A.7.10.3	Golgi UDP-N-acetylglucosamine (UDP-GlcNAc) transporter.	Animals	SLC35B4 (610923) of Homo sapiens (Q869W7)
2.A.7.11: The UDP-Galactose:UMP Antiporter (UGA) Family
2.A.7.11.1	UDP-galactose:UMP antiporter	Animals	UDP-galactose transporter isoform 1 of Homo sapiens (P78383)
2.A.7.11.2	Golgi adenosine 3'-phosphate 5'-phosphosulfate transporter, slalom (functions by an exchange mechanism, essential for viability (Kamiyama et al., 2003)).	Animals	slalom of Drosophila melanogaster (Q9VEI3)
2.A.7.11.3	Golgi adenosine 3'-phosphate 5'-phosphosulfate (PAPS): adenosine 3'-phosphate 5'-phosphate (PAP) antiporter, PAPST1. (Mutations cause human inherited disorders (orthologue of 2.A.7.11.2) (Kamiyama et al., 2003)).	Animals	PAPST1 of Homo sapiens (Q8TB61)
2.A.7.11.4	Golgi UDP-galactose/UDP-glucose:UDP antiporter, UTr1 (Norambuena et al., 2002)	Animals	UTr1 of Arabidopsis thaliana (O64503)
2.A.7.11.5	Translocates 3’ phosphoadenosine 5’ phosphosulfate, PAPS, the high-energy sulfate donor from the cytosol to the Golgi lumen for sulfation of glycoproteins, proteoglycans and glycolipids.	Animals	SLC35B3 (610845) of Homo sapiens (Q9H1N7)
2.A.7.12: The CMP-Sialate:CMP Antiporter (CSA) Family
2.A.7.12.1	CMP-sialic acid:CMP antiporter	Animals	CMP-sialic acid transporter of Mus musculus (Q61420)
2.A.7.12.2	CMP-Sialic Acid Transporter (CMP-SAT)	Insect	CMP-SAT of Aedes aegypti (Q175F9)
2.A.7.12.3	UDP-Galactose Transporter, UTR6	Plants	UTR6 of Arabidopsis thaliana (Q9C5H6)
2.A.7.12.4	Golgi UDP-galactose and UDP-N-acetylglucosamine:UDP antiporter, SRF-3 (Hoflich et al., 2004).	Animals	SRF-3 of Caenorhabditis elegans (Q93890)
2.A.7.12.5	Golgi UDP galactose and UDP-N-acetylgalactosamine:UDP antiporter, UGT (Segawa et al., 2002)	Animals	UGT of Drosophila melanogaster (Q9W4W6)
2.A.7.12.6	Golgi UDP galactose and UDP-N-acetylgalactosamine: UDP antiporter UGT (orthologue of 2.A.7.12.5) (Segawa et al., 2002)	Animals	UGT of Homo sapiens (P78381)
2.A.7.12.7	Golgi UDP-N-acetylglucosamine transporter (Ishida et al., 1999a).	Animals	UDP-GlcNAc of Homo sapiens (Q9Y2D2)
2.A.7.12.8	UDP-galactose transporter, UGT (Had-1) (Ishida et al., 1999b)	Animals	UGT of Mus musculus (Q9R0M8)
2.A.7.12.9	The ER/Golgi UDP-N-acetylgalactosamine (and possibly UDP-N-acetylglucosamine) transporter C03H5.2 gene product (Caffaro et al., 2006)	Round worm	C03H52 of Caenorhabditis elegans (O16658)
2.A.7.12.10	The ZK896.9 golgi apparatus nucleotide sugar transporter (transports UDP-glucose, UDP-galactose, UDP- N-acetylglucosamine, and UDP- N-acetylgalactosamine) (Caffaro et al., 2008)	Metazoa	ZK896.9 of Caenorhabditis elegans (O02345)
2.A.7.12.11	Golgi CMP-sialic acid:CMP exchange transporter. Used for glycosylation within the Golgi lumen.	Animals	SLC35A1 (605634) of Homo sapiens (P78382)
2.A.7.12.12	Putative golgi UDP-sugar transporter, SLC35A4	Animals	SLC35A4 of Homo sapiens (Q9ZR72)
2.A.7.12.13	Putative nucleotide-sugar transporter, C2orf18 (371aas; 9 TMSs)	Animals	C2orf18 of Homo sapiens (Q8N357)
2.A.7.13: The GDP-Mannose:GMP Antiporter (GMA) Family
2.A.7.13.1	GDP-mannose:GMP antiporter, (vanadate resistance protein)VRG4	Animals, yeast	VRG4 of Saccharomyces cerevisiae (P40107)
2.A.7.13.2	Golgi GDP-mannose transporter, VRG4	Yeast	VRG4 of Candida albicans (Q96WN8)
2.A.7.13.3	Golgi GDP Mannose: GDP antiporter, GONST1 (Baldwin et al., 2001).	Plants	GONST1 of Arabidopsis thaliana (Q941R4)
2.A.7.14: The Plant Organocation Permease (POP) Family
2.A.7.14.1	Purine/pyrimidine organocation uptake permease, AtPUP1	Plants	AtPUP1 of Arabidopsis thaliana
2.A.7.15: The UDP-glucuronate/UDP-N-acetylgalactosamine Transporter (UGnT) Family
2.A.7.15.1	The UDP-N-acetyl glucosamine/UDP-glucose/GDP-mannose transporter, SQV7L	Animals	SQV7L of Homo sapiens (Q76EJ3)
2.A.7.15.2	The golgi UDP-glucuronate/UDP-galactose transporter, SQV-7	Animals	SQV-7 (yk46f1.5) of Caenorhabditis elegans (Q18779)
2.A.7.15.3	Endoplasmic reticulum (ER)/Golgi antiporter for UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose in exchange for UDP, fringe connection (Frc) (essential for several signalling pathways) (Selva et al., 2001).	Animals	Frc of Drosophila melanogaster (Q95YI5)
2.A.7.15.4	The UDP glucuronate/UDP-N-acetylgalactosamine transporter, Slc35D1; responsible for Schneckenbecken dysplasia in humans (Hiraoka et al., 2007)	Animals	Slc35D1 of Homo sapiens (Q9NTN3)
2.A.7.15.5	The putative golgi UDP-sugar transporter SLC35D3 (416aas, 10 TMSs)	Animals	SLC35D3 of Homo sapiens (Q5M8T2)
2.A.7.16: The GDP-fucose Transporter (GFT) Family
2.A.7.16.1	The GDP fucose transporter (GFT) (defective in human leukocyte adhesion disease II)	Animals	GFT of Homo sapiens (Q96A29)
2.A.7.16.2	Golgi GDP-fucose transporter, CG9620 (Luhn et al., 2004)	Animals	CG9620 of Drosophila melanogaster (Q9VHT4)
2.A.7.17: The Aromatic Amino Acid/Paraquat Exporter (ArAA/P-E) Family
2.A.7.17.1	Aromatic amino acid exporter (exports Phe, Tyr, Trp, and their toxic analogues (Doroshenko et al., 2007)). Also called the paraquat (methyl viologen) exporter, YddG (also exports benzyl viologen).	Gram-negative proteobacteria	YddG of Salmonella typhimurium
2.A.7.18: The Choline Uptake Transporter (LicB-T) Family
2.A.7.18.1	The high-affinity choline uptake transporter, LicB	Bacteria	LicB of Haemophilus influenzae (AAC23188)
2.A.7.18.2	The archael putative permease MttP1 (MA0530) possibly a methyl amine uptake porter; D.J. Ferguson, personal communication) (10 putative TMSs)	Archaeal	MttP1 of Methanosarcina acetivorans (Q8TTA6)
2.A.7.18.3	The archael putative permease MttP2 (MA0929) (possibly a methyl amine uptake porter; D.J Ferguson, personal communication). (9 putative TMSs; The N-terminal TMS may be missing).	Archaeal	MttP2 of Methanosarcina acetivorans (Q8TS76)
2.A.7.19: The Nucleobase Uptake Transporter (NBUT) Family
2.A.7.19.1	Allantoin permease, UPS1 (may also transport uracil and 5-fluorouracil) (10 TMSs) (Schmidt et al., 2004)	Plants	UPS1 of Phaseolus vulgaris (French bean) (AAS19930)
2.A.7.19.2	The uptake transporter for allantoin (Km = 50 μM) and other oxo derivatives of nitrogen heterocyclic compounds, UPS1 (ureide: H⁺ symport permease) (10 TMSs; 5 paralogues in Arabidopsis) (also transports purine degradation products such as uric acid and xanthine but not adenine) (Desimone et al., 2002)	Plants	UPS1 of Arabidopsis thaliana (Q9ZPR7)
2.A.7.20: The Chloroquine Resistance Transporter (PfCRT) Family
2.A.7.20.1	Chloroquine resistance transporter, PfCRT. Martin et al. (2009) have demonstrated Chloroquine transport via the malaria parasite's chloroquine resistance transporter. Possibly, PfCRT catalyzes electrochemically downhill diffusion out of the digestive vacuole, in response to ΔΨ or ΔpH (Paguio et al., 2009).	Protozoans, animals	PfCRT of Plasmodium falciparum (AF495378)
2.A.7.21: The 5 TMS Bacterial/Archaeal Transporter-2 (BAT2) Family
2.A.7.21.1	The putative toxoflavin exporter, ToxF (co-transcribed with an RND-type toxoflavine exporter, Tox GHI) (Kim et al., 2004)	Bacteria	ToxF of Burkholderia glumae (AAV52811)
2.A.7.21.2	Putative exporter	Bacteria	YdcZ of E. coli (P76111)
2.A.7.21.3	Putative exporter	Archaea	Putative exporter of Methanococcus maripaludis (CAF29821)
2.A.7.21.4	The orotate transporter, OroP (Defoor et al., 2007) (also, transports 5-fluoroorotate)	Bacteria	OroP of Lactococcus lactis (Q3SAW5)
2.A.7.22: The 4 TMS Small Multidrug Resistance-2 (SMR2) Family
2.A.7.22.1	The YfbW protein of unknown function	Bacteria	YfbW of E. coli (Q47377)
2.A.7.22.2	The undecaprenyl phosphate-α-aminoarabinose flippase ArnE/ArnF heterodimer from the cytoplasm to the periplasm (Yan et al., 2007).	Bacteria	ArnE/ArnF flippase of Salmonella enterica ArnE (111aas; 4 TMSs) (P81891) ArnF (125aas; 4 TMSs) (Q8ZNF0)
2.A.7.23: The Putative Tryptophan Efflux (Trp-E) Family
2.A.7.23.1	The putative tryptophan efflux protein, Ycbk	Bacteria	YcbK of Bacillus subtilis (P42243)
2.A.7.23.2	SepJ, a novel composite protein of 751 aas needed for cellular filament integrity, proper heterocyst development and N2 fixation. It has a C-terminal DME family domain (Flores et al., 2007). Mullineaux et al. (2008) have proposed that this protein (SepJ; FraG) may be a channel-forming protein for transfer of metabolites between cells.	Bacteria	SepJ of Anabaena sp. PCC7120 (Q8YUK6)
2.A.7.24: The Thiamine Pyrophosphate Transporter (TPPT) Family
2.A.7.24.1	The mitochondrial thiamine-repressible putative thiamine pyrophosphate (TPP) transporter, Thi74 (370 aas; 10 TMSs in a 2 + 8 arrangement) (Mojzita and Hohmann, 2006)	Yeast	Thi74 of Saccharomyces cerevisiae (Q04083)
2.A.7.24.2	The DUF6-domain transporter homologue, TrH1	Slime mold	TrH1 of Dictyostelium discoideum (Q54E05)
2.A.7.24.3	The DUF6-domain transporter homologue, TrH2 (392 aas; 10 TMSs in a 2 + 4 + 4 arrangement)	Animals	TrH2 of Caenorhabditis elegans (Q95XC7)
2.A.7.24.4	The At3g07080 DUF6 domain transporter homologue	Plants	At3g07080 of Arabidopsis thaliana (Q9SFT8)
2.A.7.24.5	The DUF6 domain transporter homologue, TrH3 (299 aas; 10 TMSs in a 2 + 8 arrangement)	Bacteria	TrH3 of Candidatus Pelagibacter ubique (Q4FKW8)
2.A.7.24.6	The DUF6-domain-containing solute carrier family 35, member F5 (523 aas; 10 TMSs, 2 + 4 + 4)	Animals	Family 35 member F5 of Homo sapiens (Q8WV83)
2.A.7.24.7	The putative thiamine pyrophosphate transporter, SLC35E4	Animals	SLC35E4 of Homo sapiens (Q6ICL7)
2.A.7.25: The NIPA Mg²⁺ Uptake Permease (NIPA) Family
2.A.7.25.1	The nonimprinted in Prader-Willi/Angelman syndrome, subtype 1, NIPA1 Mg²⁺ uptake permease (329aas; 9TMSs) (Quamme, 2009)	Animals	NIPA of Homo sapiens (Q7RTP0)
2.A.7.25.2	The nonimprinted in Prader-Willi/Angelman syndrom, subtype 2, NIPA2 protein (360 aas; 9TMSs, 43% identical with NIPA1) Mg²⁺ transport is electrogenic, voltage dependent, and saturable, a K_Mof 0.31mM (very selective for Mg²⁺). (Goytain et al. 2008)	Animals	NIPA2 of Homo sapiens (Q8N8Q9)
2.A.7.25.3	NIPA3 protein (406 aas)	Animals	NIPA3 of Homo sapiens (Q6P499)
2.A.7.25.4	The ichthyin (ICHN) austosomal recessive congeital ichthyosis (ARCI) disease protein (404 aas; 9TMSs)	Animals	ICHN of Homo sapiens (Q0D2K0)
2.A.7.25.5	The permease-related protein (PRP) (335 aas; 9TMSs)	Plants	PRP of Arabidopsis thaliana (Q9LIR9)
2.A.7.25.6	Hypothetical protein (HP)	Fungi	HP of Neurospora crassa (Q7RWT8)
2.A.7.25.7	Protein AN62992 (691 aas; 9TMSs at the N-terminus (1-300 aas)). The C-terminal region (DUF803) is very hydrophobic.	Fungi	AN62992 of Aspergillus nidulans (Q5AZI1)
2.A.7.26: The 2 or 4 TMS Small Multidrug Resistance-3 (SMR3) Family
2.A.7.26 The 4 TMS Small Multidrug Resistance-3 (SMR3) Family YnfA is a 108 aa E. coli protein with 4 established TMSs and both the N- and C-termini in the periplasm (Drew et al., 2002). Its homologues are found in a broad range of Gram-negative and Gram-positive bacteria as well as archaea and eukaryotes. The sizes of bacterial homologues range from 98 aas to 132 aas, with a few exceptions. Plant proteins can be as large as 197aas. The first two TMSs are homologous to the second two in these 4 TMS proteins. A Methanosarciniae mazei homologue of 94 aas and a Geobacillus kaustophilus homologue of 104 aas have only 2 TMSs with 30 residue extensions C- and N-terminal, respectively. No functional data are available for any of its homologues. This family is the YnfA UPF0060 family.
2.A.7.26.1	YnfA (4 TMSs)	Bacteria	YnfA of E. coli
2.A.7.26.2	MA_3936 (4 TMSs)	Archaea	MA_3936 of Methanosarcina acetivorans (gi#19918023)
2.A.7.26.3	Sitka Spruce 4 TMS YnfA family homologue (144aas).	Plants	YnfA homologue of Picea sitchensis (ADE77612)
2.A.7.26.4	Moss 4-5 TMS YnfA family homologue (197aas)	Plants	YnfA homologue of Physcomitrella patens (A9T501)
2.A.7.26.5	Hypothetical protein, GK2092 (2 TMSs)	Bacteria	GK2092 of Geobacillus kaustophilus (Q5KY59)
2.A.7.26.6	Conserved protein, MM_0735 (2 TMSs)	Archaea	MM_0735 of Methanosarcina mazei (Q8PYW4)