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TCID	Name	Organismal Type	Example
2.A.7.1: The 4 TMS Small Multidrug Resistance (SMR) Family
2.A.7.1.1	Small multidrug efflux pump, Smr (QacC, QacD, Ebr). Substrates: (1) aromatic dyes (e.g., ethidium bromide), (2) quarternary amines (e.g., the disinfectant benzalkonium) and (3) derivatives of tetraphenylphosphonium (TPP) (Fuentes et al. 2005).	Bacteria	Smr of Staphylococcus aureus
2.A.7.1.2	Small multidrug efflux pump (substrates: tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y)	Bacteria	Mmr of Mycobacterium tuberculosis (P69926)
2.A.7.1.3	Small multidrug efflux pump (substrates: cationic lipophilic drugs). The 3-D structure of the dimeric EmrE shows opposite orientation of the two subunits in the membrane (Chen et al., 2007). There may be a single intermediate state in which the substrate is occluded and immobile (Basting et al., 2008). A Gly₉₀X₆Gly₉₇ motif is important for dimer formation (Elbaz et al., 2008).	Bacteria	EmrE of E. coli
2.A.7.1.4	Quaternary ammonium compound (cetylpyridinium, cetyldimethyl ethylammonium, hexadecyltrimethyl ammonium) efflux pump	Bacteria	SugE of E. coli (P69937)
2.A.7.1.5	The heterooligomeric drug resistance efflux pump, YkkCD (substrates: ethidium bromide, proflavin, tetraphenylarsonium chloride, crystal violet, pyronin Y, methylviologen, cetylperdinium chloride, streptomycin, tetracycline, chloramphenicol, phosphonomycin)	Bacteria	YkkCD of Bacillus subtilis
2.A.7.1.6	The heterooligomeric drug resistance efflux pump, EbrAB (substrates: ethidium bromide, acriflavin, pyronin Y, and safranin O) (Zhang et al., 2007).	Bacteria	EbrAB of Bacillus subtilis
2.A.7.1.7	The drug resistance efflux pump, Hsmr (Ninio and Schuldiner, 2003) (exports ethidium, acriflavin tetraphenylphosphonium (TPP) and other cationic drugs). Inhibited by a peptide with the sequence of TMS4 (Poulsen and Deber 2012).	Archaea	Hsmr of Halobacterium salinarum (B0R6K7)
2.A.7.1.8	The putative heterodimeric SMR efflux pump, NepAB, encoded in a nicotine degradation plasmid, pAO1 (Baitsch et al., 2001; Brandsch, 2006); [probably exports methylamine; may also export excess nicotine, methylamine and/or the intermediate of nicotine catabolism, N-methyl-aminobutyrate] (Ganas et al. 2007). Uptake (Km=6μM) occurs by facilitated diffusion (Ganas and Brandsch, 2009).	Bacteria	NepAB of Arthrobacter nicotinovorans: NepA (116 aas; Q8GAI5) NepB (166 aas; Q8GAI6)
2.A.7.1.9	The spermidine exporter, MdtJI (Higashi et al., 2008)	Bacteria	MdtJI of E. coli MdtJ (P69213) MdtI (P69210)
2.A.7.1.10	SugE Supressor of GroEL/ES (He et al., 2011). Confers resistance to cetyltrimethylammonium bromide, cetylpyridinium chloride, tetraphenylphosphonium, benzalkonium chloride, ethidium bromide, and sodium dodecyl sulfate.	Bacteria	SugE of Enterobacter cloacae (D5CES3)
2.A.7.1.11	Small MDR pump, AbeS (53% identical to EmrE of E. coli; TC# 2.A.7.1.3). Exports chloramphenicol, ciprofloxacin, erythromycin, novobiocin, acridine orange, acriflavine, benzalkonium chloride, DAPI, deoxycholate, ethidium bromide, sodium dodecyl sulfate (SDS), and tetraphenylphosphonium (Srinivasan et al., 2009).	Bacteria	AbeS of Acinetobacter baumannii (Q2FD83)
2.A.7.2: The 5 TMS Bacterial/Archaeal Transporter (BAT) Family
2.A.7.2.1	Hypothethical protein	Bacteria	Ycb6 of Pseudomonas denitrificans
2.A.7.2.2	Hypothethical protein	Archaea	Orf of Pyrococcus abyssi
2.A.7.3: The 10 TMS Drug/Metabolite Exporter (DME) Family
2.A.7.3.1	Putative acetate efflux pump, MadN	Bacteria	MadN of Malonomonas rubra
2.A.7.3.2	YdeD (EamA) efflux pump for O-acetylserine, cysteine, asparagine and glutamine (Dassler et al., 2000; Franke et al. 2003)	Bacteria	YdeD of E. coli
2.A.7.3.3	PecM Probable blue pigment (indigoidine) exporter	Bacteria	PecM of Erwinia chrysanthemi
2.A.7.3.4	YwfM	Bacteria	YwfM of Bacillus subtilis
2.A.7.3.5	Yf33	Archaea	Yf33 of Archaeoglobus fulgidus
2.A.7.3.6	RhtA (YbiF) Threonine/Homoserine Exporter (may export other amino acids including proline, serine, cysteine, histidine and several amino acid analogues, based on resistance phenotypes (Livshits et al., 2003))	Bacteria	RhtA (YbiF) of Escherichia coli (P0AA67)
2.A.7.3.7	The S-adenosylmethionine uptake transporter, Sam (Tucker et al., 2003) (may function by an exchange mechanism (i.e., S-adenosyl- methionine/S-adenosylhomocysteine exchange))	Bacteria	Sam (RPO76) of Rickettsia prowazekii
2.A.7.3.8	10 TMS DMT superfamily member of unknown function. In an operon with glucan biosynthesis protein C and the AgnG (2.A.66.5.1) exporter. Regulated by RpiR (ribose regulator).	Bacteria	Permease of Agrobacterium tumefaciens (A9CFB8)
2.A.7.3.9	10 TMS DMT superfamily member of unknown function.	Bacteria	Permease of Vibriocholerae (A2P528)
2.A.7.3.10	DUF6 domain protein of unknown function	Bacteria	DUF6 protein of Rhodococccus erythropolis (C3JHC4)
2.A.7.3.11	Putative porter, SACE_6693, of unknown function	Actinobacteria	SACE_6693 of Saccharopolyspora erythraea (A4FP84)
2.A.7.3.12	10 TMS YicL protein of 307aas; function unknown, but may export protoporphyrin IX (Kanjo et al., 2001).	Bacteria	YicL of E.coli (P31437)
2.A.7.3.13	Putative Drug/Metabolite Exporter	Bacteria	DME of Mannheimia haemolytica (A7JQ96)
2.A.7.3.14	Putative Drug/Metabolite Exporter	Bacteria	DME of Comamonas testeroni (D8D9B1)
2.A.7.3.15	Putative DUF6 protein	Bacteria	DUF6 protein of Xanthomonas vesicatoria (F0BFS6)
2.A.7.3.16	DMT Superfamily member	Bacteria	DMT member of Chlamydia trachomatis (D6YX63)
2.A.7.3.17	Putative transporter of 10TMSs (TMSs 5-10 are possibly homologous to TMSs 1-6 in LanG (9.A.29.1.1)). LanG shows limited sequence similarity to ABC porters.	Bacteria	Putative transporter of Chlamydophila abortus (Q5L5M5)
2.A.7.3.18	DUF6 homologue, YhbE	Bacteria	YhbE of E. coli (E1ILD8)
2.A.7.3.19	Possible L-alanine exporter, YtfF (Hori et al., 2011).	Bacteria	YtfF of E. coli (P39314)
2.A.7.3.20	S-adenosylmethionine/S-adenosylhomocysteine transporter (SAM/SAH transporter) (SAMHT; CTL843).� May function in SAM uptake and SAH export, perhaps by an SAM/SAH antiport mechanism (Binet et al. 2011).	Bacteria	SAMHT of Chlamydia trachomatis serovar L2
2.A.7.3.22	YedA transporter	Bacteria	YedA of E. coli (P0AA70)
2.A.7.3.23	Uncharacterized transporter BU281	Bacteria	BU281 of Buchnera aphidicola subsp. Acyrthosiphon pisum
2.A.7.3.24	Uncharacterized transporter YdeK	Bacilli	YdeK of Bacillus subtilis
2.A.7.3.25	Protein PagO	Bacteria	PagO of Salmonella typhimurium
2.A.7.3.26	Uncharacterized inner membrane transporter, YijE. Probable amino acid exporter (Zakataeva et al., 2006 (PMID 17025177)	Bacteria	YijE of Escherichia coli O6:H1
2.A.7.3.27	Uncharacterized transporter BUsg_270	Bacteria	BUsg_270 of Buchnera aphidicola subsp. Schizaphis graminum
2.A.7.3.28	Uncharacterized transporter AF_0266	Archaea	AF_0266 of Archaeoglobus fulgidus
2.A.7.3.29	Uncharacterized transporter YoaV	Bacilli	YoaV of Bacillus subtilis
2.A.7.3.30	Uncharacterized transporter HI_0976.1	Bacteria	HI_0976.1 of Haemophilus influenzae
2.A.7.3.31	Uncharacterized transporter ydeD	Bacilli	YdeD of Bacillus subtilis
2.A.7.3.32	Uncharacterized transporter YdfC	Bacilli	YdfC of Bacillus subtilis
2.A.7.3.33	DME family member	Actinobacteria	DME family member of Streptomyces coelicolor
2.A.7.3.34	DME family member	Actinobacteria	DME family member of Streptomyces coelicolor
2.A.7.3.35	Uncharacterized transporter YetK	Bacilli	YetK of Bacillus subtilis
2.A.7.3.36	Uncharacterized transporter AF_0510	Archaea	AF_0510 of Archaeoglobus fulgidus
2.A.7.3.37	The DUF6 domain transporter homologue, TrH3 (299 aas; 10 TMSs in a 2 + 8 arrangement)	Bacteria	TrH3 of Candidatus Pelagibacter ubique (Q4FKW8)
2.A.7.3.38	Uncharacterized transporter YrdR	Bacilli	YrdR of Bacillus subtilis
2.A.7.3.39	Putative transporter	Actinobacteria	Putative transporter of Streptomyces coelicolor
2.A.7.3.40	Putative transporter	Proteobacteria	Putative transporter of Myxococcus xanthus
2.A.7.3.41	Hypothetical protein, HP	Bacteria	HP of Streptomyces coelicolor (Q9AK99)
2.A.7.3.42	Putative riboflavin porter, ImpX. Regulated by FMN riboswitch (Vitreschak et al. 2002)	Bacillales	ImpX of Bacillus clausii (Q5WDG6)
2.A.7.3.43	Uncharacterized transporter	Actinobacteria	Uncharacterized protein of Streptomyces coelicolor
2.A.7.3.44	Hypothetical protein of 302 aas and 10 TMSs	Archaea	HP of Halarcula hispanica
2.A.7.3.45	Hypothetical protein of 363 aas and 10 TMSs	Planctomycetes	HP of Rhodopirellula baltica
2.A.7.3.46	Hypothetical protein	Planctomycetes	HP of Rhodopirellula baltica
2.A.7.3.47	10 TMS DME homologue of 280 aas	Archaea	DME homologue of Pyrococcus abyssi
2.A.7.3.48	Multidrug resistance pump, EmrE	Actinobacteria	EmrE of Blastococcus saxobsidens
2.A.7.3.49	Peptidase S8 & S53 Subtilisin/kexin/sedolisin. Has an N-terminal 10 (or 11) TMSs followed by a large hydrophilic domain that includes the protease domain.	Actinobacteria	Peptidase with N-terminal 10 TMSs of Micromonospora aurantiaca
2.A.7.4: The Plant Drug/Metabolite Exporter (P-DME) Family
2.A.7.4.1	MtN21 nodulin protein	Plants	MtN21 of Medicago truncatula
2.A.7.4.2	Nodulin MfN21	Plants	MfN21 of Arabidopsis thaliana (NP_173898)
2.A.7.4.3	Nodulin MtN21/EamA-like transporter	Plants	Nodulin MtN21 of Arabidopsis thaliana (Q9ZUI8)
2.A.7.5: The Glucose/Ribose Porter (GRP) Family
2.A.7.5.1	Glucose uptake permease, GlcU	Gram-positive bacteria	GlcU (GltT) of Staphylococcus xylosus
2.A.7.5.2	Probable ribose transporter, RbsU	Gram-positive bacteria	RbsU of Lactobacillus sakei
2.A.7.5.3	Glucose:H⁺ symporter, GlcU (YxfA) (high specificity, low affinity) (Castro et al., 2009)	Low G+C, Gram-positive Bacteria	GlcU of Lactococcus lactis (Q9CDF7)
2.A.7.5.4	Glucose permease, GlcU (also called YcxE). (Fiegler et al., 1999) (most similar to 2.A.7.5.1).	Bacteria	GlcU of Bacillus subtilis (P40420)
2.A.7.6: The L-Rhamnose Transporter (RhaT) Family
2.A.7.6.1	Rhamnose:H⁺ symporter, RhaT	Gram-negative bacteria	RhaT of E. coli
2.A.7.7: The Chloramphenicol-Sensitivity Protein (RarD) Family
2.A.7.7.1	The chloramphenicol-sensitive protein, RarD	Gram-negative bacteria	RarD of Pseudomonas aeruginosa
2.A.7.7.2	Protein RarD. Involved in antibiotic resistance (Carruthers et al. 2010).	Bacteria	RarD of Escherichia coli
2.A.7.7.3	Uncharacterized transporter HI_0680	Bacteria	HI_0680 of Haemophilus influenzae
*2.A.7.8: The Caenorhabditis elegans* ORF (CEO) Family**
2.A.7.8.1	Hypothetical protein, Yrr6	Animals	Yrr6 of Caenorhabditis elegans
2.A.7.8.2	TM protein 144 homologue 2 (DUF1632 homologue).	Slime molds	TMP144-2 of Dictyostelium discoideum (Q54V96)
2.A.7.9: The Triose-phosphate Transporter (TPT) Family
2.A.7.9.1	Chloroplast triose-P/glycerate-3-P:P_i antiporter (TPT) (phosphoenolpyruvate and 2-phosphoglycerate are poor substrates).	Plants	TPT of Zea mays
2.A.7.9.2	Nongreen plastid/chloroplast glucose-P/triose-P/glycerate-P:P_i antiporter (GPT) (Both glucose-6-P and glucose-1-P are substrates; other hexose-Ps may also be transported). (Exchanges phosphoenolpyruvate for inorganic phosphate (Nozawa et al., 2007)	Plants	GPT of Brassica oleracea
2.A.7.9.3	Chloroplast phosphoenolpyruvate:P_i antiporter (PPT) (triose-Ps and glycerate- Ps are poor substrates).	Plants	PPT of Zea mays
2.A.7.9.4	Sly41p (transport function unknown)	Yeast	Sly41p of Saccharomyces cerevisiae
2.A.7.9.5	The plastidic phosphate/triosephosphate transporter, TPT (Linka et al., 2008).	Red algae	TPT Galdieria sulphuraria (B5AJT1)
2.A.7.9.6	Chloroplast Glucose-6-P/P_iantiporter-2, Gpt2	Plants	Gpt2 of Arabidopsis thaliana (Q94B38)
2.A.7.9.7	solute carrier family 35, member E2B	Animals	SLC35E2B of Homo sapiens
2.A.7.9.8	solute carrier family 35, member C2	Homo sapiens	SLC35C2 of Homo sapiens (Q8VCX2)
2.A.7.9.9	solute carrier family 35, member E1	Animals	SLC35E1 of Homo sapiens
2.A.7.9.10	solute carrier family 35, member E3	Animals	member E3 of Mus musculus (Q6PGC7)
2.A.7.9.11	The putative thiamine pyrophosphate transporter, SLC35E4	Animals	SLC35E4 of Homo sapiens
2.A.7.9.12	UDP-galactose, UDP glucose and UDP fructose transporter 2, UGAL2 (At1g76670; EamA superfamily)	Plants	UGAL2 of Arabidopsis thaliana (Q9SRE4)
2.A.7.9.13	Golgi nucleotide-sugar (probable UDP-galactose) transporter (At1g21070; EamA superfamily).	Plants	At1g21070 of Arabidopsis thaliana (Q9LPU2)
2.A.7.9.14	Putative nucleotide-sugar transporter YMD8	Fungi	YMD8 of Saccharomyces cerevisiae
2.A.7.9.15	Solute carrier family 35 member E3 (Bladder cancer-overexpressed gene 1 protein)	Animals	SLC35E3 of Homo sapiens
2.A.7.9.16	Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein)	Animals	SLC35C2 of Homo sapiens
2.A.7.9.17	Probable sugar phosphate/phosphate translocator At2g25520	Plants	At2g25520 of Arabidopsis thaliana
2.A.7.9.18	Putative transporter C83.11	Yeast	SPBC83.11 of Schizosaccharomyces pombe
2.A.7.9.19	Glucose-6-phosphate/phosphate-translocator-like protein 1	Plants	At4g03950 of Arabidopsis thaliana
2.A.7.10: The UDP-N-Acetylglucosamine:UMP Antiporter (UAA) Family
2.A.7.10.1	UDP-N-acetylglucosamine:UMP antiporter	Yeast, animals	Mnn2-2 of Kluyveromyces lactis
2.A.7.10.2	The bifunctional golgi nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine, SLC35B4 (Ashikov et al., 2005).	Animals	SLC35B4 of Homo sapiens
2.A.7.10.3	Golgi UDP-N-acetylglucosamine (UDP-GlcNAc) transporter.	Animals	SLC35B4 (610923) of Homo sapiens (Q869W7)
2.A.7.11: The UDP-Galactose:UMP Antiporter (UGA) Family
2.A.7.11.1	UDP-galactose:UMP antiporter	Animals	SLC35B1 of Homo sapiens
2.A.7.11.2	Golgi adenosine 3'-phosphate 5'-phosphosulfate transporter, slalom (functions by an exchange mechanism, essential for viability (Kamiyama et al., 2003)).	Animals	slalom of Drosophila melanogaster (Q9VEI3)
2.A.7.11.3	Golgi adenosine 3'-phosphate 5'-phosphosulfate (PAPS): adenosine 3'-phosphate 5'-phosphate (PAP) antiporter, PAPST1. (Mutations cause human inherited disorders (orthologue of 2.A.7.11.2) (Kamiyama et al., 2003)).	Animals	SLC35B2 of Homo sapiens
2.A.7.11.4	Golgi UDP-galactose/UDP-glucose:UDP antiporter, UTr1 (Norambuena et al., 2002)	Animals	UTr1 of Arabidopsis thaliana (O64503)
2.A.7.11.5	Translocates 3’ phosphoadenosine 5’ phosphosulfate, PAPS, the high-energy sulfate donor from the cytosol to the Golgi lumen for sulfation of glycoproteins, proteoglycans and glycolipids.	Animals	SLC35B3 of Homo sapiens
2.A.7.11.6	UDP-galactose transporter homolog 1 (Multicopy suppressor of leflunomide-sensitivity protein 6)	Fungi	HUT1 of Saccharomyces cerevisiae
2.A.7.11.7	UDP-galactose/UDP-glucose transporter 5 (AtUTr5)	Plants	UTR5 of Arabidopsis thaliana
2.A.7.12: The CMP-Sialate:CMP Antiporter (CSA) Family
2.A.7.12.1	CMP-sialic acid:CMP antiporter. Amino acid residues important for CMP-sialic acid recognition have been identified (Takeshima-Futagami et al., 2012).	Animals	CMP-sialic acid transporter of Mus musculus (Q61420)
2.A.7.12.2	CMP-Sialic Acid Transporter (CMP-SAT)	Insect	CMP-SAT of Aedes aegypti (Q175F9)
2.A.7.12.3	UDP-Galactose Transporter, UTR6	Plants	UTR6 of Arabidopsis thaliana (Q9C5H6)
2.A.7.12.4	Golgi UDP-galactose and UDP-N-acetylglucosamine:UDP antiporter, SRF-3 (Hoflich et al., 2004).	Animals	SRF-3 of Caenorhabditis elegans (Q93890)
2.A.7.12.5	Golgi UDP galactose and UDP-N-acetylgalactosamine:UDP antiporter, UGT (Segawa et al., 2002)	Animals	UGT of Drosophila melanogaster (Q9W4W6)
2.A.7.12.6	Golgi UDP galactose and UDP-N-acetylgalactosamine: UDP antiporter UGT (orthologue of 2.A.7.12.5) (Segawa et al., 2002)	Animals	SLC35A2 of Homo sapiens
2.A.7.12.7	Golgi UDP-N-acetylglucosamine transporter (Ishida et al., 1999a).	Animals	SLC35A3 of Homo sapiens
2.A.7.12.8	UDP-galactose transporter, UGT (Had-1) (Ishida et al., 1999b)	Animals	UGT of Mus musculus (Q9R0M8)
2.A.7.12.9	The ER/Golgi UDP-N-acetylgalactosamine (and possibly UDP-N-acetylglucosamine) transporter C03H5.2 gene product (Caffaro et al., 2006)	Round worm	C03H52 of Caenorhabditis elegans (O16658)
2.A.7.12.10	The ZK896.9 golgi apparatus nucleotide sugar transporter (transports UDP-glucose, UDP-galactose, UDP- N-acetylglucosamine, and UDP- N-acetylgalactosamine) (Caffaro et al., 2008)	Metazoa	ZK896.9 of Caenorhabditis elegans (O02345)
2.A.7.12.11	Golgi CMP-sialic acid:CMP exchange transporter. Used for glycosylation within the Golgi lumen. Amino acid residues important for CMP-sialic acid recognition have been identified (Takeshima-Futagami et al., 2012).	Animals	SLC35A1 of Homo sapiens
2.A.7.12.12	Putative golgi UDP-sugar transporter, SLC35A4	Animals	SLC35A4 of Homo sapiens
2.A.7.12.13	Putative nucleotide-sugar transporter, C2orf18 (371aas; 9 TMSs)	Animals	C2orf18 of Homo sapiens (Q8N357)
2.A.7.12.14	Probable UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5)	Animals	SLC35A5 of Homo sapiens
2.A.7.12.15	CMP-sialic acid transporter 5 (CMP-SA-Tr 5) (CMP-Sia-Tr 5)	Plants	At5g65000 of Arabidopsis thaliana
2.A.7.13: The GDP-Mannose:GMP Antiporter (GMA) Family
2.A.7.13.1	GDP-mannose:GMP antiporter, (vanadate resistance protein)VRG4	Animals, yeast	VRG4 of Saccharomyces cerevisiae (P40107)
2.A.7.13.2	Golgi GDP-mannose transporter, VRG4	Yeast	VRG4 of Candida albicans (Q96WN8)
2.A.7.13.3	Golgi GDP Mannose: GDP antiporter, GONST1 (Baldwin et al., 2001).	Plants	GONST1 of Arabidopsis thaliana (Q941R4)
2.A.7.13.4	GDP-mannose transporter GONST3 (Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 3)	Plants	GONST3 of Arabidopsis thaliana
2.A.7.14: The Plant Organocation Permease (POP) Family
2.A.7.14.1	Purine/pyrimidine organocation uptake permease, AtPUP1	Plants	AtPUP1 of Arabidopsis thaliana
2.A.7.14.2	Probable purine permease 18 (AtPUP18)	Plants	Pup18 of Arabidopsis thaliana
2.A.7.14.3	Probable purine permease 11 (AtPUP11)	Plants	PUP11 of Arabidopsis thaliana
2.A.7.14.4	Purine permease 2 (AtPUP2)	Plants	PUP2 of Arabidopsis thaliana
2.A.7.14.5	Putative purine permease 15 (AtPUP15)	Plants	PUP15 of Arabidopsis thaliana
2.A.7.15: The UDP-glucuronate/UDP-N-acetylgalactosamine Transporter (UGnT) Family
2.A.7.15.1	The UDP-N-acetyl glucosamine/UDP-glucose/GDP-mannose transporter, SQV7L	Animals	SLC35D2 of Homo sapiens
2.A.7.15.2	The golgi UDP-glucuronate/UDP-galactose transporter, SQV-7	Animals	SQV-7 (yk46f1.5) of Caenorhabditis elegans (Q18779)
2.A.7.15.3	Endoplasmic reticulum (ER)/Golgi antiporter for UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose in exchange for UDP, fringe connection (Frc) (essential for several signalling pathways) (Selva et al., 2001).	Animals	Frc of Drosophila melanogaster (Q95YI5)
2.A.7.15.4	The UDP glucuronate/UDP-N-acetylgalactosamine transporter, Slc35D1; responsible for Schneckenbecken dysplasia in humans (Hiraoka et al., 2007)	Animals	SLC35D1 of Homo sapiens
2.A.7.15.5	The putative golgi UDP-sugar transporter SLC35D3 (416aas, 10 TMSs)	Animals	SLC35D3 of Homo sapiens
2.A.7.16: The GDP-fucose Transporter (GFT) Family
2.A.7.16.1	The GDP fucose transporter (GFT) (defective in human leukocyte adhesion disease II) (SLC35C1)	Animals	SLC35C1 of Homo sapiens
2.A.7.16.2	Golgi GDP-fucose transporter, CG9620 (Luhn et al., 2004)	Animals	CG9620 of Drosophila melanogaster (Q9VHT4)
2.A.7.16.3	Uncharacterized transporter C22F8.04	Yeast	SPAC22F8.04 of Schizosaccharomyces pombe
2.A.7.17: The Aromatic Amino Acid/Paraquat Exporter (ArAA/P-E) Family
2.A.7.17.1	Aromatic amino acid exporter (exports Phe, Tyr, Trp, and their toxic analogues (Doroshenko et al., 2007)). Also called the paraquat (methyl viologen) exporter, YddG (also exports benzyl viologen and possibly L-alanine; Hori et al., 2011). The topology of YddG has been shown to be 10 TMSs with N- and C- termini on the inside (Airich et al., 2010).	Gram-negative proteobacteria	YddG of Salmonella typhimurium
2.A.7.17.2	Aromatic amino acid exporter YddG. Its topology with 10 TMSs and both the N- and C-termini inside has been established (Airich et al. 2010).	Bacteria	YddG of Escherichia coli
2.A.7.18: The Choline Uptake Transporter (LicB-T) Family
2.A.7.18.1	The high-affinity choline uptake transporter, LicB	Bacteria	LicB of Haemophilus influenzae (AAC23188)
2.A.7.18.2	The archaeal putative permease MttP 353 aas (lMA0530) possibly a methyl amine uptake porter; D.J. Ferguson, personal communication) (10 putative TMSs)	Archaeal	MttP of Methanosarcina acetivorans (Q8TTA7)
2.A.7.18.3	The archael putative permease MttP2 (MA0929) (possibly a methyl amine uptake porter; D.J Ferguson, personal communication). (9 putative TMSs; The N-terminal TMS may be missing).	Archaeal	MttP2 of Methanosarcina acetivorans (Q8TS76)
2.A.7.18.4	LicB-T family member	Actinobacteria	LicB-T family member of Streptomyces coelicolor
2.A.7.19: The Nucleobase Uptake Transporter (NBUT) Family
2.A.7.19.1	Allantoin permease, UPS1 (may also transport uracil and 5-fluorouracil) (10 TMSs) (Schmidt et al., 2004)	Plants	UPS1 of Phaseolus vulgaris (French bean) (AAS19930)
2.A.7.19.2	The uptake transporter for allantoin (Km = 50 μM) and other oxo derivatives of nitrogen heterocyclic compounds, UPS1 (ureide:H⁺ symport permease) (10 TMSs; 5 paralogues in Arabidopsis). Also transports purine degradation products such as uric acid and xanthine but not adenine (Desimone et al., 2002).	Plants	UPS1 of Arabidopsis thaliana (Q9ZPR7)
2.A.7.20: The Chloroquine Resistance Transporter (PfCRT) Family
2.A.7.20.1	Chloroquine resistance transporter, PfCRT. Martin et al. (2009) have demonstrated Chloroquine transport via the malaria parasite's chloroquine resistance transporter. PfCRT cotransports chloroquine and H⁺out of the digestive vacuole (and hence away from its site of action) via a mutant form of the parasite's chloroquine resistance transporter (Lehane and Kirk, 2010).	Protozoans	PfCRT of Plasmodium falciparum (AF495378)
2.A.7.20.2	Crt homolog 1 (Chloroquine resistance transporter paralog 1) (DdCRTp1)	Amoeba	Crtp1 of Dictyostelium discoideum
2.A.7.21: The 5 TMS Bacterial/Archaeal Transporter-2 (BAT2) Family
2.A.7.21.1	The putative toxoflavin exporter, ToxF (co-transcribed with an RND-type toxoflavine exporter, Tox GHI) (Kim et al., 2004)	Bacteria	ToxF of Burkholderia glumae (AAV52811)
2.A.7.21.2	Putative exporter	Bacteria	YdcZ of E. coli (P76111)
2.A.7.21.3	Putative exporter	Archaea	Putative exporter of Methanococcus maripaludis (CAF29821)
2.A.7.21.4	The orotate transporter, OroP (Defoor et al., 2007) (also, transports 5-fluoroorotate)	Bacteria	OroP of Lactococcus lactis (Q3SAW5)
2.A.7.22: The 4 TMS Small Multidrug Resistance-2 (SMR2) Family
2.A.7.22.1	4-amino-4-deoxy-L-arabinose phosphoundecaprenol flippase, ArnEF [ArnE, 111aas; 4 TMSs; PmrL; YfbW] [ArnF, 128aas; 4 TMSs; PmrM; YfbJ] Functions in modification of lipid A during biosynthesis of lipopolysaccharide. Required for resistance to polymyxin and cationic antimicrobial peptides (Yan et al., 2007).	Bacteria	ArnEF of E. coli ArnE (Q47377) ArnF (P76474)
2.A.7.22.2	The undecaprenyl phosphate-α-aminoarabinose flippase ArnE/ArnF heterodimer from the cytoplasm to the periplasm (Yan et al., 2007).	Bacteria	ArnEF flippase of Salmonella typhi ArnE (P81891) ArnF (125aas; Q8Z537)
2.A.7.23: The Putative Tryptophan Efflux (Trp-E) Family
2.A.7.23.1	The putative tryptophan efflux protein, YcbK	Bacteria	YcbK of Bacillus subtilis (P42243)
2.A.7.23.2	SepJ, a novel composite protein of 751 aas needed for cellular filament integrity, proper heterocyst development and N2 fixation. It has a C-terminal DME family domain (Flores et al., 2007). Mullineaux et al. (2008) have proposed that this protein (SepJ; FraG) may be a channel-forming protein for transfer of metabolites between cells.	Bacteria	SepJ of Anabaena sp. PCC7120 (Q8YUK6)
2.A.7.24: The Thiamine Pyrophosphate Transporter (TPPT) Family
2.A.7.24.1	The mitochondrial thiamine-repressible putative thiamine pyrophosphate (TPP) transporter, Thi74 (370 aas; 10 TMSs in a 2 + 8 arrangement) (Mojzita and Hohmann, 2006)	Yeast	Thi74 of Saccharomyces cerevisiae (Q04083)
2.A.7.24.2	The DUF6-domain transporter homologue, TrH1	Slime mold	TrH1 of Dictyostelium discoideum (Q54E05)
2.A.7.24.3	The DUF6-domain transporter homologue, TrH2 (392 aas; 10 TMSs in a 2 + 4 + 4 arrangement)	Animals	TrH2 of Caenorhabditis elegans (Q95XC7)
2.A.7.24.4	The At3g07080 DUF6 domain transporter homologue	Plants	At3g07080 of Arabidopsis thaliana (Q9SFT8)
2.A.7.24.5	Uncharacterized vacuolar membrane protein YML018C	Fungi	YML018C of Saccharomyces cerevisiae
2.A.7.24.6	The DUF6-domain-containing solute carrier family 35, member F5 (523 aas; 10 TMSs, 2 + 4 + 4)	Animals	SLC35F5 of Homo sapiens
2.A.7.24.7	DUF6 domain-containing protein with 150aa N-terminal hydrophilic extension	Fungi	DUF6 protein of Trichophyton equinum (F2PXJ5)
2.A.7.24.8	The thiamin uptake transporter, SLC35F3. Involved in hypertension.	Animals	SLC35F3 of Homo sapiens
2.A.7.24.9	SLC family 35 member F1 (SLC35F1; also called DUF914)	Animals	SLC35F1 of Homo sapiens
2.A.7.24.10	SLC family 35 member F2 (SLC35F2; also called DUF914)	Animals	SLC35F2 of Homo sapiens
2.A.7.24.11	SLC family 35 member F2 (SLC35F2; also called DUF914)	Animals	SLC35F2 of Aspergillus fumigatus (Q4WUA9)
2.A.7.24.12	DUF914 protein, possibly anthocyanin-related protein-1 (Anm1)	Animals	DUF914 protein of Arabidopsis thaliana (Q948Q9)
2.A.7.24.13	Protein of unknown function (claimed to have extra cytoplasmic N- and C-termini (Västermark et al., 2011)). The 10 TMSs occur in a 6+4 arrangement.	Protozoa	Unknown protein of Trypanosoma brucei (Q57UU3)
2.A.7.24.14	Solute carrier family 35 member F4	Animals	SLC35F4 of Homo sapiens
2.A.7.24.15	Uncharacterized DMT superfamily homologue	Fungi	Uncharacterized protein of Lodderomyces elongisporus
2.A.7.25: The NIPA Mg²⁺ Uptake Permease (NIPA) Family
2.A.7.25.1	The nonimprinted in Prader-Willi/Angelman syndrome, subtype 1, NIPA1 Mg²⁺ uptake permease (329aas; 9TMSs) (Quamme, 2009)	Animals	NIPA of Homo sapiens (Q7RTP0)
2.A.7.25.2	The nonimprinted in Prader-Willi/Angelman syndrom, subtype 2, NIPA2 protein (360 aas; 9TMSs, 43% identical with NIPA1) Mg²⁺ transport is electrogenic, voltage dependent, and saturable, a K_Mof 0.31mM (very selective for Mg²⁺). (Goytain et al. 2008)	Animals	NIPA2 of Homo sapiens (Q8N8Q9)
2.A.7.25.3	NIPA3 protein (406 aas)	Animals	NIPA3 of Homo sapiens (Q6P499)
2.A.7.25.4	The ichthyin (ICHN) austosomal recessive congeital ichthyosis (ARCI) disease protein (404 aas; 9TMSs)	Animals	ICHN of Homo sapiens (Q0D2K0)
2.A.7.25.5	The permease-related protein (PRP) (335 aas; 9TMSs)	Plants	PRP of Arabidopsis thaliana (Q9LIR9)
2.A.7.25.6	Hypothetical protein (HP)	Fungi	HP of Neurospora crassa (Q7RWT8)
2.A.7.25.7	Protein AN62992 (691 aas; 9TMSs at the N-terminus (1-300 aas)). The C-terminal region (DUF803) is very hydrophobic.	Fungi	AN62992 of Aspergillus nidulans (Q5AZI1)
2.A.7.25.8	Membrane protein	Actinobacteria	Membrane protein of Corynebacterium matruchotii (E0DBX6)
2.A.7.25.9	Magnesium transporter NIPA3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3 homolog)	Animals	Nipal1 of Mus musculus
2.A.7.25.10	NIPA family member	Actinobacteria	NIPA family member of Streptomyces coelicolor
2.A.7.26: The 2 or 4 TMS Small Multidrug Resistance-3 (SMR3) Family
2.A.7.26 The 2 or 4 TMS Small Multidrug Resistance-3 (SMR3) Family YnfA is a 108 aa E. coli protein with 4 established TMSs and both the N- and C-termini in the periplasm (Drew et al., 2002). Its homologues are found in a broad range of Gram-negative and Gram-positive bacteria as well as archaea and eukaryotes. The sizes of bacterial homologues range from 98 aas to 132 aas, with a few exceptions. Plant proteins can be as large as 197aas. The first two TMSs are homologous to the second two in these 4 TMS proteins. A Methanosarciniae mazei homologue of 94 aas and a Geobacillus kaustophilus homologue of 104 aas have only 2 TMSs with 30 residue extensions C- and N-terminal, respectively. No functional data are available for any of its homologues. This family is the YnfA UPF0060 family.
2.A.7.26.1	YnfA (4 TMSs)	Bacteria	YnfA of E. coli
2.A.7.26.2	MA_3936 (4 TMSs)	Archaea	MA_3936 of Methanosarcina acetivorans (gi#19918023)
2.A.7.26.3	Sitka Spruce 4 TMS YnfA family homologue (144aas).	Plants	YnfA homologue of Picea sitchensis (ADE77612)
2.A.7.26.4	Moss 4-5 TMS YnfA family homologue (197aas)	Plants	YnfA homologue of Physcomitrella patens (A9T501)
2.A.7.26.5	Hypothetical protein, GK2092 (2 TMSs)	Bacteria	GK2092 of Geobacillus kaustophilus (Q5KY59)
2.A.7.26.6	Conserved protein, MM_0735 (2 TMSs)	Archaea	MM_0735 of Methanosarcina mazei (Q8PYW4)
2.A.7.27: The Ca²⁺ Homeostasis Protein (Csg2) Family
2.A.7.27.1	Csg2 (Cls2) Ca² homeostasis protein. Cells lacking Csg2p accumulate Ca² in a pool which is exchangeable with extracellular Ca² . The mutant cells are Ca² sensitive. The protein has 410 amino acyl residues, with 9-10 TMSs. It exhibits an EF-hand Ca² binding motif on the lumenal side of the endoplasmic reticular membrane. It is possible that it functions in Ca² sequestration. It regulates the activities of CSH1 and SUR1 during mannosyl phosphorylinositol ceramid synthesis. It forms heterodimers with CSH1 and SUR1 (Beeler et al. 1994; Takita et al. 1995). Cls2p likely functions in releasing Ca² from the endoplasmic reticulum, somehow cooperating with calcineurin (Tanida et al. 1996). It regulates the transport and protein leves of the inositol phosphorlyceramide mannosyltransferases Csg1 and Csh1 (Uemura et al. 2007).	Yeast	Csg2 of Saccharomyces cerevisiae (P35206)
2.A.7.28: The Solute Carrier 35G (SLC35G) Family
2.A.7.28.1	Solute carrier family 35 member G1	Animals	SLC35G1 of Homo sapiens (Q8BY79)
2.A.7.28.2	Solute carrier family 35 member G2	Animals	SLC35G2 of Homo sapiens
2.A.7.28.3	Solute carrier family 35 member G3	Animals	SLC35G3 of Homo sapiens (Q5F297)
2.A.7.28.4	Solute carrier family 35 member G4	Animals	SLC35G4 of Homo sapiens
2.A.7.28.5	Solute carrier family 35 member G5	Animals	SLC35G5 of Homo sapiens
2.A.7.28.6	Solute carrier family 35 member G6	Animals	SLC35G6 of Homo sapiens
2.A.7.28.7	Solute carrier family 35 member G3 (Acyl-malonyl-condensing enzyme 1) (Transmembrane protein 21A)	Animals	SLC35G3 of Homo sapiens
2.A.7.28.8	Solute carrier family 35 member G1 (Transmembrane protein 20)	Animals	SLC35G1 of Homo sapiens
2.A.7.28.9	Uncharacterized transporter HP_1234	Bacteria	HP_1234 of Helicobacter pylori
2.A.7.29: The Uncharacterized DMT-1 (U-DMT1) Family
2.A.7.29.1	10 TMS DMT superfamily member	Planctomycetes	DMT member of Rhodopirellula baltica
2.A.7.30: The Uncharacterized DMT-2 (U-DMT2) Family
2.A.7.30.1	Hypothetical protein of 299 aas and 10 putative TMSs	Planctomycetes	HP of Rhodopirellula baltica
2.A.7.31: The Uncharacterized DMT-3 (U-DMT3) Family
2.A.7.31.1	10 TMS DMT Superfamily member	δ-Proteobacteria	DMT protein of Myxococcus xanthus (Q1DCP3)
2.A.7.31.2	10 TMS DMT Superfamily member	γ-Proteobacteria	Legionella pneumophila (A5IFT5)
2.A.7.31.3	10 TMS DMT Superfamily member	α-Proteobacteria	DMT protein of Rhizobium torpici (L0LHM3)