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2.A.7.15.4
The UDP glucuronate/UDP-N-acetylgalactosamine transporter, Slc35D1; responsible for Schneckenbecken dysplasia in humans (Hiraoka et al., 2007)

Accession Number:Q9NTN3
Protein Name:Slc35D1
Length:355
Molecular Weight:39240.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate UDP-glucuronate, UDP-N-acetylgalactosamine

Cross database links:

Genevestigator: Q9NTN3 Q9NTN3
eggNOG: prNOG12255 NOG261892
HEGENOM: HBG381255 HOG000038339
RefSeq: NP_055954.1   
Entrez Gene ID: 23169   
Pfam: PF03151   
OMIM: 269250  phenotype
610804  gene
KEGG: hsa:23169    hsa:23169   

Gene Ontology

GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005461 F:UDP-glucuronic acid transmembrane transport...
GO:0005463 F:UDP-N-acetylgalactosamine transmembrane tra...
GO:0030206 P:chondroitin sulfate biosynthetic process
GO:0006065 P:UDP-glucuronate biosynthetic process
GO:0015789 P:UDP-N-acetylgalactosamine transport
GO:0005461 F:UDP-glucuronic acid transmembrane transporter activity
GO:0005463 F:UDP-N-acetylgalactosamine transmembrane transporter activity
GO:0006805 P:xenobiotic metabolic process

References (12)

[1] “Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity.”  Muraoka M.et.al.   11322953
[2] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.”  Hiraoka S.et.al.   17952091
[7] “Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity.”  Muraoka M.et.al.   11322953
[8] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.”  Hiraoka S.et.al.   17952091

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEVHRRQHA RVKGEAPAKS STLRDEEELG MASAETLTVF LKLLAAGFYG VSSFLIVVVN 
61:	KSVLTNYRFP SSLCVGLGQM VATVAVLWVG KALRVVKFPD LDRNVPRKTF PLPLLYFGNQ 
121:	ITGLFSTKKL NLPMFTVLRR FSILFTMFAE GVLLKKTFSW GIKMTVFAMI IGAFVAASSD 
181:	LAFDLEGYAF ILINDVLTAA NGAYVKQKLD SKELGKYGLL YYNALFMILP TLAIAYFTGD 
241:	AQKAVEFEGW ADTLFLLQFT LSCVMGFILM YATVLCTQYN SALTTTIVGC IKNILITYIG 
301:	MVFGGDYIFT WTNFIGLNIS IAGSLVYSYI TFTEEQLSKQ SEANNKLDIK GKGAV