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2.A.7.3.12
10 TMS YicL protein of 307aas; function unknown, but may export δ-levulinate or protoporphyrin IX (Kanjo et al., 2001).

Accession Number:P31437
Protein Name:Uncharacterized inner membrane transporter yicL
Length:307
Molecular Weight:33113.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Protoprophyrin IX, delta-levulinate

Cross database links:

Genevestigator: P31437
EchoBASE: EB1639
EcoGene: EG11688
eggNOG: COG0697
HEGENOM: HBG702365
Entrez Gene ID: 948176   
Pfam: PF00892   
KEGG: ecj:JW3634    eco:b3660   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (4)

[1] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGSTRKGMLN VLIAAVLWGS SGVCAQYIME QSQMSSQFLT MTRLIFAGLI LLTLSFVHGD 
61:	KIFSIINNHK DAISLLIFSV VGALTVQLTF LLTIEKSNAA TATVLQFLSP TIIVAWFSLV 
121:	RKSRPGILVF CAILTSLVGT FLLVTHGNPT SLSISPAALF WGIASAFAAA FYTTYPSTLI 
181:	ARYGTLPVVG WSMLIGGLIL LPFYARQGTN FVVNGSLILA FFYLVVIGTS LTFSLYLKGA 
241:	QLIGGPKASI LSCAEPLSSA LLSLLLLGIT FTLPDWLGTL LILSSVILIS MDSRRRARKI 
301:	NRPARHK