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2.A.74.1.1
Lysosomal mouse 4 TMS transporter protein, MTP (transports thymidine, uridine, both purine and pyrimidine nucleosides including adenosine, drugs, ionophores and steroids)

Accession Number:Q60961
Protein Name:MTRP aka MTP aka LAPTM4A
Length:233
Molecular Weight:26858.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Thymidine, Uridine, Adenosine, Nucleosides, drugs, Ionophores, steroids

Cross database links:

Genevestigator: Q60961
eggNOG: roNOG10499
HEGENOM: HBG713795
Pfam: PF03821   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (2)

[1] “Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae.”  Hogue D.L.et.al.   8621662
[2] “Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.”  Ballif B.A.et.al.   18034455

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV 
61:	NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF 
121:	VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFV VFIIFKAYLI 
181:	NCVWNCYKYI NNRNVPEIAV YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA