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2.A.74.1.2
Lysosomal 4 TMS retanoic acid-inducible E3 protein.  May play a special functional role during embryogenesis and in adult hematopoietic cells (Adra et al. 1996).

Accession Number:Q61168
Protein Name:LAM5 aka E3 aka LAPTM5
Length:261
Molecular Weight:29602.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Lysosome membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q61168
DIP: DIP-37698N
RefSeq: NP_034816.1   
Entrez Gene ID: 16792   
Pfam: PF03821   
KEGG: mmu:16792   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005765 C:lysosomal membrane
GO:0006810 P:transport

References (4)

[1] “LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.”  Adra C.N.et.al.   8661146
[2] “E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.”  Scott L.M.et.al.   8839844
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.”  Cao L.et.al.   17947660

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC RFFKMPYLRM 
61:	ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI MDFLLCLLTL LGSYIELPAY 
121:	LKLARPRPGP SKVPLMTLQL LDFCLSILTL CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH 
181:	SQFINMMLIF SVAFITVLIL KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE 
241:	ALSLPPKTPE GDPAPPPYSE V