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2.A.76.1.2
Threonine efflux permease (probable threonine:H+ antiporter), RhtC (YigJ).  Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Accession Number:P0AG38
Protein Name:Threonine efflux protein RhtC aka YigJ aka B3823
Length:206
Molecular Weight:22474.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Threonine, H+

Cross database links:

Genevestigator: P0AG38
EchoBASE: EB1436
EcoGene: EG11468
eggNOG: COG1280
HEGENOM: HBG759042
RefSeq: AP_003977.1    YP_026264.1   
Entrez Gene ID: 948317   
Pfam: PF01810   
BioCyc: EcoCyc:RHTC-MONOMER   
KEGG: ecj:JW5586    eco:b3823   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006865 P:amino acid transport

References (7)

[1] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.”  Daniels D.L.et.al.   1379743
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “The recQ gene of Escherichia coli K12: primary structure and evidence for SOS regulation.”  Irino N.et.al.   3027506
[6] “The novel transmembrane Escherichia coli proteins involved in the amino acid efflux.”  Zakataeva N.P.et.al.   10386596
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLMLFLTVAM VHIVALMSPG PDFFFVSQTA VSRSRKEAMM GVLGITCGVM VWAGIALLGL 
61:	HLIIEKMAWL HTLIMVGGGL YLCWMGYQML RGALKKEAVS APAPQVELAK SGRSFLKGLL 
121:	TNLANPKAII YFGSVFSLFV GDNVGTTARW GIFALIIVET LAWFTVVASL FALPQMRRGY 
181:	QRLAKWIDGF AGALFAGFGI HLIISR