TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.76.1.1









Homoserine/homoserine lactone/β-hydroxynorvaline efflux permease (probable substrate:H+ antiporter), RhtB (YigK).  Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Bacteria
Proteobacteria
RhtB of E. coli (P0AG34)
*2.A.76.1.2









Threonine efflux permease (probable threonine:H+ antiporter), RhtC (YigJ).  Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Bacteria
Proteobacteria
RhtC (YigJ) of E. coli (P0AG38)
*2.A.76.1.3









Probable amino acid exporter, YahN of 233 aas and 6 TMSs.  Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Bacteria
Proteobacteria
YahN of E. coli (P75693)
*2.A.76.1.4









O-aetylserine/cysteine/azaserine exporter, EamB or YfiK (Franke et al., 2003).  

Bacteria
Proteobacteria
EamB or YfiK of E. coli
*2.A.76.1.5









The leucine exporter (LeuE; YeaS) (binds and probably transports L-methionine, L-histidine, L-α-amino-n-butyrate, norleucine, azaleucine, S(2-aminoethyl)-L-cysteine, 3,4-dehydro-DL-proline, L-alanine, and both D- and L-valine) (Kutukova et al., 2005; Hori et al., 2011).  Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Bacteria
Proteobacteria
LeuE of E. coli (P76249)
*2.A.76.1.6









The RhtB family member, RSP_2720

Bacteria
Proteobacteria
RSP_2070 of Rhodobacter sphaeroides (Q3J2V9)
*2.A.76.1.7









Putative amino acid exporter of 208 aas; RhtB family member; similar to 2.A.76.1.5.

Bacteria
Firmicutes
RhtB family member of Bacillus subtilis
*2.A.76.1.8









Putative amino acid efflux porter of 210 aas, YrhP.  Most similar to 2.A.76.1.5 of the characterized proteins in TCDB.

Bacteria
Firmicutes
YrhP of Bacillus subtilis
*2.A.76.1.9









Exporter for L-homoserine, L-serine, and L-homoserine lactone as well as the quorum-sensing pimaricin-inducer PI-factor (2,3-diamino-2,3-bis(hydroxymethyl)-1,4-butanediol), PimT (Vicente et al. 2009).

Bacteria
Actinobacteria
PimT of Streptomyces natalensis
*2.A.76.1.10









RhtB family porter of 210 aas and 6 TMSs.  Based on homology, may export serine, threonine, homoserine and/or homoserine lactones.  Possibly regulated by a LysR transcription factor.  The gene maps adjacent to a probable heterodimeric DMT superfamily transporter (2.A.7.21.5).

Bacteria
Proteobacteria
RhtB family homologue of Klebsiella oxytoca
*2.A.76.1.11









Amino acid exporter of 210 aas and 6 TMSs, MrsC.  Encoded by the mrsC gene in an operon for the biosynthesis of the toxic amino acid analogue, 3-methyarginine, the likely substrate (Braun et al. 2010).  The epiphytic Pseudomonas syringae strain which produces and excretes 3-methyarginine does so to compete with pathogenic strains of P. syringae for which 3-methyarginine is toxic.

Bacteria
Proteobacteria
MrsC of Pseudomonas syringae
*2.A.76.1.12









Uncharacterized amino acid transporter of 207 aas and 6 TMSs.

Bacteria
Candidatus Wolfebacteria
UP of Candidatus Wolfebacteria bacterium
*2.A.76.1.13









LysE superfamily member of 220 aas and 6 TMSs in a 3 + 3 arrangement

Archaea
Candidatus Lokiarchaeota
LysE member of Lokiarchaeum sp. GC14_75 (from a marine sediment metagenome)
*2.A.76.2.1









Potential coronamic acid exporter of 236 aas and 5 TMSs.  Coronamic acid (CMA), an ethylcyclopropyl amino acid derived from isoleucine, functions as an intermediate in the biosynthesis of coronatine, a chlorosis-inducing phytotoxin produced by Pseudomonas syringae pv. glycinea PG4180. The DNA required for CMA biosynthesisincludes three distinct open reading frames (ORFs) which share a common orientation for transcription.  Two ORFs in the operon include CmaT, a thioesterase and CmaU, a potential exporter (Ullrich and Bender 1994).

Bacteria
Proteobacteria
CmaU of Pseudomonas syringae
*2.A.76.2.2









CmaU of 203 aas and 5 or 6 TMSs.  This protein resembles 2.A.76.2.1; one or the other may be an incomplete or inaccurate sequence.

Bacteria
Proteobacteria
CmaU of Pseudomonas syringae
*2.A.76.2.3









CmaU homologue of 203 aas and 6 TMSs.

Bacteria
Proteobacteria
CmaU of Achromobacter xylosoxidans
*2.A.76.3.1









Uncharacterized probable amino acid exporter of 230 aas and 6 TMSs.

Bacteria
Bacteroidetes
UP of Croceibacter atlanticus