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2.A.8.1.2
L-Idonate/D-Gluconate:H+ symporter, IdnT, GntW, YjgT (Bausch et al., 1998)

Accession Number:P39344
Protein Name:IDNT aka GntW aka YjgT aka B4265
Length:439
Molecular Weight:46041.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate l-idonate, D-gluconate, H+

Cross database links:

Genevestigator: P39344
EchoBASE: EB2428
EcoGene: EG12539
eggNOG: COG2610
HEGENOM: HBG649941
DIP: DIP-10014N
RefSeq: AP_004761.1    NP_418686.1   
Entrez Gene ID: 948798   
Pfam: PF02447   
BioCyc: EcoCyc:YJGT-MONOMER    ECOL168927:B4265-MONOMER   
KEGG: ecj:JW4222    eco:b4265   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015128 F:gluconate transmembrane transporter activity
GO:0015292 F:uniporter activity
GO:0019521 P:D-gluconate metabolic process
GO:0015725 P:gluconate transport

References (5)

[1] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Sequence analysis of the GntII (subsidiary) system for gluconate metabolism reveals a novel pathway for L-idonic acid catabolism in Escherichia coli.”  Bausch C.et.al.   9658018
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPLIIIAAGV ALLLILMIGF KVNGFIALVL VAAVVGFAEG MDAQAVLHSI QNGIGSTLGG 
61:	LAMILGFGAM LGKLISDTGA AQRIATTLIA TFGKKRVQWA LVITGLVVGL AMFFEVGFVL 
121:	LLPLVFTIVA SSGLPLLYVG VPMVAALSVT HCFLPPHPGP TAIATIFEAN LGTTLLYGFI 
181:	ITIPTVIVAG PLFSKLLTRF EKAPPEGLFN PHLFSEEEMP SFWNSIFAAV IPVILMAIAA 
241:	VCEITLPKTN TVRLFFEFVG NPAVALFIAI VIAIFTLGRR NGRTIEQIMD IIGDSIGAIA 
301:	MIVFIIAGGG AFKQVLVDSG VGHYISHLMT GTTLSPLLMC WTVAALLRIA LGSATVAAIT 
361:	TAGVVLPIIN VTHADPALMV LATGAGSVIA SHVNDPGFWL FKGYFNLTVG ETLRTWTVME 
421:	TLISIMGLLG VLAINAVLH