| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
2.A.92.1.1 | The skeletal muscle, Na+-dependent, choline transporter-like protein, CTL-1 (SLC44A1; 653 aas) (Yuan et al., 2004) (Present in the plasma membrane, mitochondria and endosomes; catalyzes choline uptake into mitochondria (Michel and Bakovic, 2009). | Eukaryota |
Metazoa, Chordata | CTL-1 of Mus musculus (Q6X893) |
|
2.A.92.1.2 | The inner ear choline transporter-like transporter glycoprotein CLT-2 (CTL2; SLC44A2; 706 aas), target of autoimmune hearing loss (Nair et al., 2004; Kleopa, 2011). CTL2 co-precipitates with multiple isoforms of cochlin (TC# 8.A.54.1.3) which is mutated in individuals with DFNA9 hearing loss (Kommareddi et al. 2007). | Eukaryota |
Metazoa, Chordata | CTL-2 of Homo sapiens (Q8BY89) |
|
2.A.92.1.3 | solute carrier family 44, member 3 | Eukaryota |
Metazoa, Chordata | SLC44A3 of Homo sapiens |
|
2.A.92.1.4 | Choline/ethanolamine transporter-like protein 2, CTL2 (Solute carrier family 44 member 2, SLC44A2) of 706 aas and 9 or 10 TMSs. Slc44A2/HNA-3a is important for the adhesion and activation of neutrophils in veins under inflammation and when submitted to specific shears. The fact that neutrophils expressing Slc44a2/HNA-3b have a different response on von Willebrand factor (VWF) under the conditions tested could explain the association between HNA-3b and a reduced risk for venous thrombosis (VT) in humans (Zirka et al. 2021). See also TC# 2.A.92.1.2 for another human isoform with 91% identity. Protein Msp (Major sheath protein) is a component of the cell surface dentilisin protease complex (TC# 9.B.355.1.1). | Eukaryota |
Metazoa, Chordata | SLC44A2 of Homo sapiens |
|
2.A.92.1.5 | Choline transporter-like protein 5 (Solute carrier family 44 member 5) | Eukaryota |
Metazoa, Chordata | SLC44A5 of Homo sapiens |
|
2.A.92.1.6 | Choline/ethanolamine transporter, choline transporter-like protein 1 (CTL1; CDW92) (Solute carrier family 44 member 1, SLV44A1) (CD antigen CD92) (Taylor et al. 2021). It transports both choline and ethanolamine (Taylor et al. 2021). The transcriptional regulation and splice variation of the encoding gene have been studied (Yuan et al. 2006). It is found in many tissues including red blood cells (Bryk and Wiśniewski 2017). May be involved in neurodevelopmental disorders (Reuter et al. 2017). CTL1 and CTL2 proteins are present in the plasma membrane and mitochondria, respectively. They have intermediate affinities for choline (Iwao et al. 2016), but it has also been reported that CTL1 has high affinity for ethanolamine while CTL2 has low affinity (Taylor et al. 2021). | Eukaryota |
Metazoa, Chordata | SLC44A1 of Homo sapiens |
|
2.A.92.1.7 | Human thiamine pyrophosphate uptake porter, TPPT, a 10 TMS glycoprotein glycosylated on five asparagine residues, some of which are necessary for function (Nabokina et al. 2016). (Solute carrier family 44 member 4). | Eukaryota |
Metazoa, Chordata | SLC44A4 of Homo sapiens |
|
2.A.92.1.8 | Protein PNS1 (pH nine-sensitive protein 1) | Eukaryota |
Fungi, Ascomycota | PNS1 of Saccharomyces cerevisiae S288c |
|
2.A.92.1.9 | CTL-like protein DDB_G0288717 | Eukaryota |
Evosea | DDB_G0288717 of Dictyostelium discoideum |
|
2.A.92.1.10 | Choline transporter 1, CHER1, CLT1, SIC1, of 700 aas and 9 TMSs in a 1 + 2 + 2 + 2 + 2 TMS arrangement. It is a choline transporter involved in the regulation of choline metabolite homeostasis during root and phloem development (Dettmer et al. 2014). It is also a regulator of vesicle trafficking, including endocytosis, and is necessary for secondary plasmodesmata (PD) formation and development via the secretory trafficking regulation of proteins required for PD development, thus influencing intercellular communication (Kraner et al. 2017, Gao et al. 2017). It is required for procambium maintenance and sieve plate development (e.g. sieve plate and sieve pore elaboration) to mediate long-distance cell-to-cell communication via symplastic transport through the phloem (Dettmer et al. 2014). | Eukaryota |
Viridiplantae, Streptophyta | CHER1 of Arabidopsis thaliana |