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2.A.92.1.2
The inner ear choline transporter-like transporter glycoprotein CLT-2 (CTL2; SLC44A2; 706 aas), target of autoimmune hearing loss (Nair et al., 2004; Kleopa, 2011).  CTL2 co-precipitates with multiple isoforms of cochlin (TC# 8.A.54.1.3) which is mutated in individuals with DFNA9 hearing loss (Kommareddi et al. 2007).

Accession Number:Q8BY89
Protein Name:Choline transporter-like protein 2 aka CTL-2
Length:704
Molecular Weight:79924.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Choline

Cross database links:

Genevestigator: Q8BY89
eggNOG: roNOG08843
RefSeq: NP_690021.1   
Entrez Gene ID: 68682   
Pfam: PF04515   
KEGG: mmu:68682   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006810 P:transport

References (4)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.”  Gundry R.L.et.al.   19656770
[4] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEDDRKDAVY GTPQKYDPTF KGPIYNRGCT DVICCVLLFL AIVGYVAVGI IAWTHGDPRK 
61:	VIYPTDSRGE FCGQKGTKNA DKPFLFYFNI VKCANPLVLL EFHCPTPQIC VKQCPDRYLT 
121:	LLSARNTRDF DYYKQFCVPG FQNNKGVTEI LRDGECPAVI TPSKPLAQRC FPAIHASKGV 
181:	LMVGNETTYE DGHGARKNIT DLVEGAKKAN KILEARQLAM QIFEDYTVSW YWIIIGLVIA 
241:	MVLSLLFIVL LRFLAGIMVW VMIVMVILVL GYGIFHCYME YSRLRGEAGS DVSLVDLGFQ 
301:	TDLRVYLHLR QTWMAFMIIL SILEVVIILL LIFLRKRILI AIALIKEASR AVGHVMCSLL 
361:	YPLVTFFLLC LCIAYWASTS VFLSTSNTAV YKVVDDTACP LLRKTCNPET FPLRNESLQC 
421:	PTARCQFAFY GGESTYHRAL LGLQIFNAFM FFWLANFVLA LGQVTLAGAF ASYYWAMRKP 
481:	DDMPAFPLFS AFGRALRYHT GSLAFGSLIL AIVQIIRVML EYLDQRLKAA QNKFAKFLMV 
541:	CLKCCFWCLE KFIKFLNRNA YIMIAIYGTN FCTSARNAFF LLMRNIIRVA VLDKVTDFLF 
601:	LLGKLLIVGS VGILAFFFFT HRIRIVQDTA PPLNYYWVPI LTVIIGSYLI AHGFFSVYGM 
661:	CVDTLFLCFL EDLERNDGSA ERPYFMSSTL KKLLNKTNKK VAES