2.A.92.1.2 The inner ear choline transporter-like transporter glycoprotein CLT-2 (CTL2; SLC44A2; 706 aas), target of autoimmune hearing loss (Nair et al., 2004; Kleopa, 2011). CTL2 co-precipitates with multiple isoforms of cochlin (TC# 8.A.54.1.3) which is mutated in individuals with DFNA9 hearing loss (Kommareddi et al. 2007).
|
Accession Number: | Q8BY89 |
Protein Name: | Choline transporter-like protein 2 aka CTL-2 |
Length: | 704 |
Molecular Weight: | 79924.00 |
Species: | Mus musculus (Mouse) [10090] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
Choline |
---|
Genevestigator: |
Q8BY89
|
eggNOG: |
roNOG08843
|
RefSeq: |
NP_690021.1
|
Entrez Gene ID: |
68682
|
Pfam: |
PF04515
|
KEGG: |
mmu:68682
|
|
[1] “The transcriptional landscape of the mammalian genome.” Carninci P. et.al. 16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[3] “The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.” Gundry R.L. et.al. 19656770
[4] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B. et.al. 19349973
|
1: MEDDRKDAVY GTPQKYDPTF KGPIYNRGCT DVICCVLLFL AIVGYVAVGI IAWTHGDPRK
61: VIYPTDSRGE FCGQKGTKNA DKPFLFYFNI VKCANPLVLL EFHCPTPQIC VKQCPDRYLT
121: LLSARNTRDF DYYKQFCVPG FQNNKGVTEI LRDGECPAVI TPSKPLAQRC FPAIHASKGV
181: LMVGNETTYE DGHGARKNIT DLVEGAKKAN KILEARQLAM QIFEDYTVSW YWIIIGLVIA
241: MVLSLLFIVL LRFLAGIMVW VMIVMVILVL GYGIFHCYME YSRLRGEAGS DVSLVDLGFQ
301: TDLRVYLHLR QTWMAFMIIL SILEVVIILL LIFLRKRILI AIALIKEASR AVGHVMCSLL
361: YPLVTFFLLC LCIAYWASTS VFLSTSNTAV YKVVDDTACP LLRKTCNPET FPLRNESLQC
421: PTARCQFAFY GGESTYHRAL LGLQIFNAFM FFWLANFVLA LGQVTLAGAF ASYYWAMRKP
481: DDMPAFPLFS AFGRALRYHT GSLAFGSLIL AIVQIIRVML EYLDQRLKAA QNKFAKFLMV
541: CLKCCFWCLE KFIKFLNRNA YIMIAIYGTN FCTSARNAFF LLMRNIIRVA VLDKVTDFLF
601: LLGKLLIVGS VGILAFFFFT HRIRIVQDTA PPLNYYWVPI LTVIIGSYLI AHGFFSVYGM
661: CVDTLFLCFL EDLERNDGSA ERPYFMSSTL KKLLNKTNKK VAES