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2.A.92.1.6
Choline transporter, choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92).  The transcriptional regulation and splice variation of the encoding gene have been studied (Yuan et al. 2006). It is found in many tissues including red blood cells (Bryk and Wiśniewski 2017). May be involved in neurodevelopmental disorders (Reuter et al. 2017). CTL1 and CTL2 proteins are present in the plasma membrane and mitochondria, respectively. They have intermediate affinities for choline (Iwao et al. 2016).

Accession Number:Q8WWI5
Protein Name:Choline transporter-like protein 1
Length:657
Molecular Weight:73302.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Choline

Cross database links:

Genevestigator: Q8WWI5
eggNOG: NOG310633
HEGENOM: HOG000231655
Entrez Gene ID: 23446   
Pfam: PF04515   
KEGG: hsa:23446   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005741 C:mitochondrial outer membrane
GO:0005886 C:plasma membrane
GO:0015220 F:choline transmembrane transporter activity

References (7)

[1] “An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins.”  O'Regan S.et.al.   10677542
[2] “Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells.”  Wille S.et.al.   11698453
[3] “Molecular characterization of the family of choline transporter-like proteins and their splice variants.”  Traiffort E.et.al.   15715662
[4] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[7] “The solute carrier 44A1 is a mitochondrial protein and mediates choline transport.”  Michel V.et.al.   19357133

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS 
61:	GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ 
121:	ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN 
181:	ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL 
241:	VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT 
301:	VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG 
361:	TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK 
421:	RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK 
481:	SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML 
541:	FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC 
601:	FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA